706
www.praktickelekarenstvi.cz550715901901162343533734615075796446977287978629369681044111011831228130213851441149115661598162416941761
e1197617148020186169246
MEDICAMENTA78492940227156260392451563690848952108411881302
NOVA91892940227129264383499
Nová6023508018869140204266
přímá6316508018859120149243313
perorální6655508018860114175245307379432504533
antikoagulancia7214508018869140195225285352419484553607679750809838907
–nové8147508018882153223287342
molekuly8515508018894163217272334405458514
ve9055508018866121
výzkumu9202508018866133191253324417487
PRAKTICKÉ80737159019080160258338422459552632710
LÉKÁRENSTVÍ88197159019074149229330411488590663741833870
with550876015594120158226
Extended804876015557114157216284353415485
Prophylaxis.131887601556096162232301354381438493519565587
The1933876015556126188
American2150876015571176238274300356414482
Journal2660876015541109176213281338364
of305287601556598
Medicine3178876015596159229254310335403465
[online].367187601553094162187212279341370389
20184088876015559119175229
[cit.434587601553082107146168
2019–02–4541876015559119175227294360418479
25].5501036015563125158177
DOI:7561036015579166193213
10.1016/j.amjmed.2018.99710360155591141341882432983523964234445046096347388008708929561016107111251147
08.21731036015559122144
024.23451036015559117172193
ISSN2566103601552380136215
00029343.28101036015559123187245305363426483503
Dostupné33411036015580149195235303372441503
z:3872103601554871
https://linkinghub.elsevier.com/retrieve/pii/S000293431830852039711036015565102144215261281328363390415482535562630699766833902923984101055011960155481111681942562923083644305355816146757137507768388959551001106810941119116412221284134914131471153215891652171017641818187819392002206221212181
9.550135401576790
Lekura6791356015559120175244281340
J,1049135601555575
Kalus11531356015575136162230276
JS.14591356015555112134
Overview16221356015598159221258321348410504
of21551356015580113
betrixaban22981356015582146185223250306365436495564
and28911356015569138209
its3129135601553777127
role32851356015548115143206
in35201356015537105
clinical3655135601556894119188214271330357
practice.40411356015582120179237280306364424445
American45151356015586193256293320377437505
Journal5501516015545113181217286343369
of9481516015567100
Health‑System10771516015580142199224263331370425477524565624729
Pharmacy[online].18341516015564131188224330387444503536600669694719787849877897
2018,27591516015562122178232253
75(15),30411516015562119149205257288306
1095–110233751516015562117180240305359406461519
[cit.3922151601553386111150172
2019–02–25].41221516015562122178231298364422483538600634653
DOI:48031516015583170197217
10.2146/ajhp170785.55016760155641201412062623173824274815075766467007518108699299901009
ISSN1588167601553896154234
1079-2082.18511676015574130188248290345406470530551
Dostupné24311676015595165212253322393462525
z:2985167601556387
https://academic.oup.com/ajhp/article/75/15/1095/51020243101167601558011716123228030034838343749555462568879482087789996810371108112911861252135914061460148615541625166917231760180418301888550183601552889135199256298356408449508563625686727786841895953101410721127
10.5501994015767129156
Beyer‑Westendorf7451996015566131189252292328435496545588650721793864904944
J,1720199601555274
Verhamme18251996015573133172244303410518582
P,2439199601557279
Bauersachs25491996015573134203268307357419478548597
R.31771996015573100
Betrixaban33081996015573138179219247305365438499569
for39081996015541111151
prevention40901996015579119182241305375415443513584
of47051996015577112
venous484819960155661295502156015569138207255
thromboembolism8352156015537106144211317388459524629700770799825872977
in1842215601552593
acute19652156015556115183224284
medically228021560155102166238265322382409436493
ill280421560155245178
patients.29122156015569128167194257326365415439
European33812156015558124162229301365423492
Heart39032156015578142199237282
Journal42152156015542112181219289347374
Supplements4619215601555812519626829635955023160155107173244284335
[online].9172316015547114186214242312378409432
2018,13802316015576139198256280
20(suppl16912316015576140176224293366440470
E),21922316015573110131
E16-E2223542316015574132189233298364429
[cit.28142316015547103131173198
2019–02–25].30432316015576140198254324394455519577642679701
DOI:37752316015597188217241
10.1093/eurheartj/40472316015576134157214272338399444502573612684749809848895923972
suy017.5502476015548117176243302355365
ISSN946247601553797156238
1520–765X.12152476015573128189252323380439501571597
Dostupné18432476015594165215257328400471536
z:2410247601556288
https://academic.oup.com/eurheartjsupp/article/20/suppl_E/E16/4993363252924760155791181642372863093593964515115726447098168439039279981068114011631222129013981447150515741613168517491808184718931921196920382111218422302285232423702398245755026360155289214020526831335842649957260167073578584890696310091066112711931253131413781440
11.5502794015767119138
Iwatsuki7142796015527119177215264330383410
Y,1153279601556274
Sato12552796015557116153219
T,1502279601555871
Moritani16012796015598166204230269327394419
Y,2049279601556274
Shigenaga21512796015558125150219281349406476533
T,2712279601555770
et2811279601556098
al.2938279601555681102
Biochemical3069279601556288156214281343448473530588614
and37112796015556124193
pharmacological39332796015568137194230336393450516542610681706763821847
profile4808279601556910617255029560155316387149
of727295601556497
darexaban,8522956015566122158218273330400458525545
an14252956015554121
oral15742956015565102159185
direct1787295601556691126186243285
factor2100295601553088145187252288
Xa24162956015567123
inhibitor.2567295601552389157181250276314379416432
European30272956015556120156221291354410477
Journal35322956015540108175211280336361
of3921295601556597
Pharmacology[online].404629560155611271832193243814375025285966667227558188869119365503116015569130158177
2011,7553116015558117172219231
673(1–3),10143116015558115175205259316372400417
49–5514593116015558116182241297
[cit.1784311601552981106144165
2019–03–19].19773116015558118172224290356413477530582611630
DOI:26353116015578164190210
10.1016/j.ejphar.2011.287331160155581121321852392943473904174384995235926607167527678308909459911005
10.39053116015559113133
009.40653116015559122184200
ISSN4293311601552379135213
00142999.45343116015558122177230286346408469486
Dostupné5503276015584153200240308378446508
z:1087327601555275
https://linkinghub.elsevier.com/retrieve/pii/S001429991101239811913276015569106149219266286334368396420488541568636705773840910930992101810631125118212091270130713231379144515501596162916891728176517911852190919702016208221082133217922372299236324192473253125912654271727732820287529312983304431033165
12.5503434015767123149
Kaku7303436015565125178246
S,1004343601556384
Suzuki11163436015563129181249302329
M,147434360155103126
Saitoh16283436015563121146185250319
M,197634360155103125
Funatsu21303436015562126194251288337403
T,2562343601556275
et26663436015565104
al.2798343601556187108
Darexaban:29353436015586143179239295353423481549569
Anticoagulant35323436015578146183209265331389459526551608676713
effects4273343601556699134195253295344
in4646343601552996
mice477134360155109134190250
and5503596015559127196
human7753596015578144249306374
plasma11773596015580107164210314371
in15773596015535102
vitro,1708359601556793132169235254
antithrombotic19913596015567135172197236304340406512582651689714771
effects27903596015571105140201259301350
in31683596015535103
thrombosis32993596015549117153219324394464510535580
and39083596015567135204
bleeding41413596015580106168231302327395464
models463435960155114183253315341387
in550375601552897
mice67737560155118144202264
and9703756015570140211
effects12113756015574109145207267311361
of16013756015581115
anti‑inhibitor17463756015570139178204244272341411437509536576643682
coagulant24573756015569137197268337364422492530
complex30173756015569136244316344407465
and35113756015570140211
recombinant37523756015549111171238346418445514573642681
factor44623756015545106164208275314
VIIa.48053756015578106133192215
Thrombosis5503916015560131167233338408478524549595
Research11733916015571134180243299335390457
[online].16593916015540104172198223290352381400
2013,20883916015569129185237256
131(5),23733916015569121175199258289307
450–45627093916015569127187255321379440
[cit.3177391601554093118157179
2019–03–19].33843916015569130185238305372430495548601631650
DOI:40633916015590177203224
10.1016/j.thromres.2013.4315391601556912414519825330936440743545649456259866455040760155106143203250273337397453505525
03.11044076015572131151
016.12844076015573128183205
ISSN1517407601553794151230
00493848.17764076015572137202260318379444508530
Dostupné23354076015593162209249317387455517
z:2881407601556285
https://linkinghub.elsevier.com/retrieve/299440760155791161592292762963433784054304975515786467157838509199401002102810731135119212191280131713331389145415601606163916991738177518011862191919802026
pii/S00493848130010355504236015572981231682262883534184765345956607247808328939571013106811261184
13.5504394015767123148
Kadokura7324396015565125194262316384421479
T,1240439601556578
Kashiwa13474396015570129176243268360418
M,179443960155106128
Groenendaal19514396015586124190253321383451521578635660
D,26404396015589106
Heeringa27754396015587149212248275342412469
M,327243960155107129
et34294396015568107
al.3564439601556590111
Clinical37044396015579104129197222278336362
pharmacokinetics,40944396015577146203240345402459525579607674736775800857905927
pharmacodynamics,550455601557214019823434039745451959064771677387790395910081029
safety16084556015545104136197236296
and19324556015557124194
tolerability21544556015538103130192228287357383408433472532
of27144556015567100
darexaban,28424556015568125161222277335405464531552
an34234556015556123
oral35754556015566103162187
direct3791455601556893129190248290
factor4109455601553191148190255293
Xa44304556015568125
inhibitor,4584455601552491159184254280319384421436
in550471601552795
healthy6734716015576138194220258326380
Caucasian10824716015580138205262320367391448515
and16264716015565132202
Japanese18574716015551107177236303365412475
subjects.23604716015555121190216278336378427449
Biopharmaceutics2838471601557297165235304361398503560617677744783809865914
&37804716015567
Drug38754716015579116184254
Disposition41584716015590116161231300347371410436503572
[online].475847160155411051731992245504876015570132161180
2013,7584876015564124180232251
34(8),10384876015564127160220250268
431–44113344876015564122176233299365418
[cit.1781487601553487112151173
2019–03–19].19834876015563124180232299366424489543595625644
DOI:26564876015584172198219
10.1002/bdd.1858.29034876015564119140193248313371417489560630651705759819880902
ISSN3833487601552885142221
01422782.40834876015564120174231293351410469489
Dostupné460148760155851542002413083785505036015570132
z:710503601555376
http://doi.wiley.com/10.1002/bdd.18588145036015570107150220240287321384452478499588614640702757773829894100010451104115911791233128813521410145715291600166916911745179918591919
14.5505194015767124150
Hashimoto7245196015582139185253278382450488553
T,1306519601555669
Suzuki14035196015556123175243296323
K,1755519601556085
Kihara1868519601556189156213250308
Y,2205519601556172
et2306519601555897
al.2431519601555581102
Absorption,25615196015572143189257295366404429497565586
metabolism317651960155102164202261330400427451497601
and38055196015555123192
excretion40265196015559114169206266305330398466
of4521519601556598
darexaban464751960155661231602202763345505356015572130198
(YM150),7765356015537104203257309370401419
a12235356015561
new13125356015571134226
direct1566535601557398134194252295
factor1889535601553695152194260297
Xa22145356015573130
inhibitor2373535601552896164189258284323389426
in2827535601552997
humans.29525356015571138243300368413436
Xenobiotica34165356015573131199267338364432470495551610
[online].40545356015536100169194219287349377397
2012,44795356015565125181233253
43(6),47615356015565122153211242260
534–5475505516015563121184250310372428
[cit.1007551601553082107145167
2019–03–19].12035516015558118174226293359417482535587618637
DOI:18685516015579166193213
10.3109/00498254.2012.738045.2109551601555911413419725130536840846753159665471677583789991998310431099115011701231129113521414147915361555
ISSN3692551601552380137216
0049-8254.39365516015559123188246287351410471534554
Dostupné45185516015580148195235302372440502
z:550567601555276
http://www.tandfonline.com/doi/full/10.3109/00498254.2012.738045654567601557010714922024028732141351060662366171978785688995610251051107511431205122512811346145214981560162916541699173218011827185218971955201020312094214822032266230623662430249525532615267527372799282028842944300030523072313231933254331733823439
15.5505834015767123147
Kadokura7225836015565124194262316384420479
T,1229583601555669
Groenendaal13275836015577114180243311373441511568625650
D,2006583601558097
Heeringa21315836015578140203239265333402459
M,26195836015597119
Mol27665836015597166192
R,2987583601556184
et3100583601555997
al.3226583601555480101
Darexaban33555836015580137173234289347417476543
(YM150),3927583601553097196250302363394412
an43675836015555122
oral45185836015565102160186
direct4732583601556792128188246289
factor550599601553493150192258295
Xa8745996015579136
inhibitor,10385996015535103170195265291330395433448
has15145996015578135181
no17245996015577145
effect18985996015571104140201258301
on22275996015577146
the24015996015548116179
pharmacokinetics26085996015580148206242348405462527581609676738777802859908
of35445996015577110
digoxin.36835996015578103173241294320387409
European41215996015568133169235306369425493
Journal46435996015552121189225294351377
of5506156015569102
Drug6816156015583120189258
Metabolism96861560155100162201259329398425450495599
and15966156015558125195
Pharmacokinetics18206156015564130188224330387444509563591658720759784841890
[online].2738615601553497166192216284346375394
2014,31606156015563123179233253
39(1),34416156015563121154209233250
1–937206156015562120182
[cit.3930615601553486111150172
2019–03–19].41316156015562122178231298364423487541594624643
DOI:48026156015584171198218
10.1007/s13318–013–0141–1.550631601556311813919324731236940344549754960766171578184890395510201086114211961249130713611375
ISSN1953631601552582139218
0378-7966.22006316015561120176235274329388451514536
Dostupné27656316015582151197238305375444506
z:3299631601555074
http://link.springer.com/10.1007/34016316015567104147217237285319346371439492516564634671697764834896933948100510701176122112801335135514091464152815861619
s13318–013–0141–15506476015548101153211265319385451507559624690746800853910964
16.5506634015767126152
Kadokura7306636015565125194262316384421479
T,1238663601556073
Taniuchi13406636015560108176201268324392417
Y,1786663601556577
Inoue1891663601552895163231293
H,22136636015582103
Saito23446636015560119144183248
M,262166360155101123
et27736636015563101
al.2903663601555984105
Effect3037663601556193128189247289
of33556636015569102
food34856636015534101170241
on37556636015569137
the39216636015540108170
pharmacokinetics41206636015571140197234339396453519573601668730769794851899
of5220876015569102
darexaban,5351876015575132169229285343413471539559
an5939876015564132
oral6099876015574112170196
direct6323876015576101137198256298
factor664987601554099156198263301
Xa6978876015576133
inhibitor,714087601553299167192262288327392429444
in761387601553299
healthy7741876015575137193219257325379
Japanese8149876015549106176234302364411473
subjects.8651876015553120189215277335377426448
Int.9128876015532100137159
Journal9315876015550118186223292349374
of52201036015569102
Clinical53511036015583108133200225282340366
Pharmacology57451036015574141198234340397454520546614685742
and65151036015568136206
Therapeutics67491036015570140202239297367430497536562618667
[online].74441036015544108176202227294356385404
2013,78771036015572133188240259
51(03),81651036015573127151211269298315
200–20685091036015572133197265321381445
[cit.8982103601554496121160182
2019–03–91931036015572133188241308374433497
19].52201196015563116146165
DOI:54141196015590178204224
10.5414/CP201804.56671196015570125145208271323378421491553613673729783846911931
ISSN6627119601553490147227
0946-1965.68821196015570133196261302356408471531550
Dostupné74611196015590159206246314384452514
z:8004119601555982
http://www.dustri.com/article_8114119601557611315622624629332842051661363069976681285288991593699310581164120912631299134213681424145015121576
response_page.html?artId=10188522013560155389914621528435339946152559965872778980987891510201046109111461183122612511321139814511506156216161679
&69271356015567
doi=10.5414/CP20180470231356015565133159235288343364427489542596640709772832892948100210651129
&81811356015567
L=082761356015553115181
17.52201514015767123135
Eriksson5394151601556197124177228275344413
B58361516015575
I,5940151601553758
Turpie60271516015570129166237264326
AGG,63811516015586163244266
Lassen66761516015568128175222284353
MR,705715160155112176200
et72851516015573112
al.7426151601556995116
Prevention75711516015575111171229290358396422490559
of81591516015579112
venous83001516015568129198266335381
thromboembolism87101516015550118155222328398468532637707777804829875980
with52201676015594120159227
an54751676015566134
oral56371676015576114172198
factor58631676015541100157200265302
Xa61941676015578135
inhibitor,63571676015534102169194264290329394432447
YM150,68321676015572171226278338358
after7218167601556699143202239
total74851676015547113150209234
hip77481676015576101171
arthroplasty.79471676015566103146214250316387414471517557617632
A86081676015583
dose87191676015578146193255
finding9002167601553970138207232300370
study9400167601555596163233289
(ONYX-2).52201836015534117199263337369423454471
Journal57191836015550118186223292349374
of61221836015574107
Thrombosis62571836015566136172238344414483530554600
and68851836015564132201
Haemostasis71151836015587144206311379426466524570595640
[online].77841836015539103172197222290352380400
2010,82121836015568129184239259
8(4),85001836015568101159188206
714–72187341836015568125180246302363418
[cit.9180183601553992117156178
2019–93861836015569129185237304
03–20].52201996015563122187242302333352
DOI:56001996015587174200221
10.1111/j.1538–7836.2010.03748.x.584919960155661211411952422903373744014234765285866477147698288889499711035109611511206122712891348140414571521154316011624
ISSN7501199601553087144223
15387933.77521996015566118176237295354412470490
Dostupné82711996015586155202242310380448510
z:8810199601555477
http://doi.wiley.89161996015572109151222242289323386454480501590616642703759774
com/10.1111/j.1538–7836.2010.03748.x5220215601555812322927533338840846250955760464166869074379585491598110361095115512161238130213631418147314941556161516711724178818101868
18.52202314015767125152
Steg5404231601556096156227
Ph.G,56592316015568135156234256
Mehta594423160155104166234271329
SR,63022316015563125148
Jukema64792316015547115168228333390
JW,68972316015548153168
et70932316015566105
al.7226231601556288109
RUBY-1:73632316015569148212273304357370
a77612316015562
randomized,78512316015542100168237305411436487547618639
double‑blind,85182316015574142210279306368408480507532599669689
placebo­92362316015574101158215274344414454
‑controlled5220247601553998163231268304370396421482552
trial580124760155357298154179
of6008247601556497
the61332476015536103165
safety63262476015544102134195233292
and66472476015554121190
tolerability68652476015536101127189225283352378403427466525
of7419247601556497
the75442476015535103165
novel77372476015565132188248274
oral80392476015565102160185
factor8252247601553088145187252289
Xa85692476015566122
inhibitor8720247601552289156181250276314379416
darexaban91642476015566123159219274332401459526
(YM150)52202636015534102201255307367399
following5647263601553097124149216308334402471
acute61472636015555112179218277
coronary64532636015554119156222291348384445
syndrome.69272636015544101171240277343448511530
European74862636015556121157223294357413481
Heart79952636015578140196233276
Journal82992636015541109177214283340365
[online].8693263601553094162188213280342371390
2011,91112636015560120176223236
32(20),93752636015559117146206266297315
2541–255452202796015563125188241298354416473535
[cit.5784279601553688114152174
2019–03–20].59872796015565125181233301367426490545606636656
DOI:66712796015586173200220
10.1093/eurheartj/ehr334.69202796015565120140194249311369411466534570639701757793837862908964103210681123118112441264
ISSN8213279601552986143222
0195–668X.84642796015565121173234298365428492559582
Dostupné90742796015586155202242310380448510
z:9613279601555477
https://academic.oup.com/eurheartj/article‑lookup/doi/10.1093/eurheartj/ehr33452202956015570107149220266287334368421478537606668773798854876944101210821102115912241329137514301498153416031665172117571801182618721926196220052031208721132174221522432311238024342502257126152678274627712817287529302950300430593122317932213277334433803449351135673604364736733719377438423878393339914054
19.52203114015767124146
Sakon53933116015560119172238307
M,572831160155100122
Nakamura58793116015581138191251355422459517
M.64253116015599123
Darexaban65763116015583139176236292350420478546
(YM150)71503116015533100199254306366397
prevents75763116015570107168225285353390439
venous80433116015557118186254322368
thromboembolism84393116015539107143210315385454517622692761788813858962
in9430311601552693
Japanese9551311601554410052203276015572131198261308370
patients56193276015581140177203264332369418
undergoing60663276015579146216278315383451477545614
major670932760155116173199267304
abdominal70423276015569139210278383409476533559
surgery:76303276015558124160228291327388411
Phase80693276015575142199245308
III840532760155376388
randomized,85223276015548106174244312418443494555626646
mechanical91973276015511617823730436242945552203436015558116142
prophylaxis‑controlled,539134360155811181852553243784054625185445906266867528208588959619881013107511461166
open‑label65863436015579149213281320348405475538564
study.7179343601555898166236293308
Thrombosis75153436015570141177243349419489535560606
Research81493436015575138185247303340395462
[online].86403436015544108177202227295357386405
2012,90743436015572133189241261
130(3),93643436015573125186220279308326
e52-e5952203596015563124183218282344400
[cit.5649359601553285110149171
2019–03–20].58483596015561121177230297363422486542602633652
DOI:65283596015582169196216
10.1016/j.thromres.2012.677335960155611161361902453003553984264474855535896557617978579049279911052110711591179
06.79813596015561125147
009.81563596015561126188205
ISSN8390359601552582139218
00493848.86373596015561125190249306367432496519
Dostupné91843596015582151198238305375444506
z:5220375601555276
https://linkinghub.elsevier.com/retrieve/pii/S004938481200280053243756015570107149220266287334368396421488541569636706773840910930992101810631125118212091270130713231379144515501596162916891728176517911852190919702016208321092134217922372299236424282487254526052670273527912842290329673025308531483212
20.52203914015767131156
Gómez‑Outes54003916015581150256318370408498566605665712
A,6140391601557396
Suárez‑Gea62653916015556123180216276328366450513569
ML,68633916015597153176
Lecumberri70683916015554114172240344414477514551578
R,7674391601556285
Rocha77883916015561130188255312
E,8129391601555678
at8235391601555593
al.8356391601555581102
New84873916015579141233
parenteral87493916015568126162223290327387424482508
anticoagulants9285391601555512316018524230736652204076015571139165222290328377
in56264076015537105
development.57604076015581143201262289357429535598666704726
Therapeutic65154076015570141204241300370434502542568625
Advances71684076015587156214273341399459506
in77034076015537105
Cardiovascular78374076015584143180248274342399458505563630656714751
Disease[online].86164076015595121167230287334396429493562588614682744774793
2011,94384076015573134191238252
5(1),5220423601556393149172189
33–5954384236015562121185245302
[cit.5768423601553487112150172
2019–03–25].59694236015562123178231298365423488543605638657
DOI:66554236015583170197217
10.1177/1753944710387808.690142360155621171381912392903513844434935516096687327988549119661025108611441203126513291351
ISSN8280423601552784141220
1753-9447.85284236015563114171230267329393459516523
Dostupné90804236015583152199239306376445507
z:9615423601555275
http://journals.sagepub.com/doi/10.1177/175394471038780852204396015570107149220240287321348416484520589646672717740788847916978104811161186120612631328143414791542161016361681174017951815186919161967202820612120217122282286234524092475253125882643270227632821288029433006
21.52204554015767126145
Hinder53964556015582107175244306343
M,576745560155103126
Frick5921455601556296122178231
A,61814556015578101
Jordaan63114556015547115152220277334402
P,6741455601556872
Hesse68414556015584147194240302
G,71724556015583105
et73064556015565103
al.7438455601556186108
Direct75744556015586112149209267309
and79114556015562129199
rapid8138455601554199169195264
inhibition8431455601552996164189259285324349417485
of89454556015571104
factor9078455601553695152194260297
Xa94034556015573130
by95624556015574129
otamixaban:52204716015569107165269295349407477536603623
A58714716015573
pharmacokinetic59724716015568137194230336393450516570597665727765791847
and68484716015555123193
pharmacodynamic70694716015568137194230336393450516586643712769874899955
investigation8053471601552391146206253294319388445483508576645
in8726471601552391
patients88454716015568127164190251319356405
with92784716015590116155223
coronary9530471601555411952204876015538105173230267327
artery55764876015567103146206242303
disease.59084876015578103149211267314376395
Clinical63324876015582107132199224281339365
Pharmacology67254876015573140197233339396453518545613684741
&74944876015567
Therapeutics[online].7589487601555512518722428235241548252154760365268374781684186693499610241044
2006,86614876015571132196260281
80(6),89704876015571134168226257275
691–70292734876015572132188245301359417
[cit.5220503601553487112151173
2019–03–25].54215036015566127182235302369427492547609642662
DOI:61115036015587174201221
10.1016/j.clpt.2006.63605036015566121142195250306361404432453509535604642664728789853917939
09.73275036015566129146
002.75025036015566130188208
ISSN7739503601553087144223
00099236.79915036015566130195257320378440501523
Dostupné85435036015586155202242310380448510
z:9082503601555578
http://doi.91895036015572109151222242289323386454480501
wiley.com/10.1016/j.clpt.2006.522051960155941201452072632783344005055516096646857387938499039479749961052107811471185120712711332139614601482
09.67305196015564126144
00269025196015563128186
22.52205354015766131157
Cohen54015356015574139208269337
M,57665356015596118
Bhatt59135356015561129185222265
DL,62065356015579136159
Alexander6393535601557197158214271339408469506
JH,69275356015540120141
et7096535601555997
al.7221535601555580101
Randomized,73505356015561119186255323428453504564634654
Double‑Blind,80335356015579148215285311373412478504529596665686
Dose‑Ranging87475356015579148194256296362420487556581648718
Study949353560155569115952205516015571127
of53765516015570103
Otamixaban,55075516015588130188292317372430500558626647
a61825516015560
Novel,62715516015584152208269295315
Parenteral,66155516015566122158219286323383420478504524
Short‑Acting71675516015561129197234277311385440482508575645
Direct78405516015585111148208266308
Factor81775516015561112169211277314
Xa85195516015572129
Inhibitor,8677551601552896163188258284323388426441
in9146551601552896
Percutaneous9270551601556612516221628432338152205676015570132201269315
Coronary55635676015580146183249318375411472
Intervention.60635676015533101138197234296357425461487555623645
Circulation67365676015580106142196264289346383409477545
[online].73105676015540104172198223290352381400
2007,77385676015569130194252258
115(20),80255676015569116168198258318349367
2642–265184205676015569129194251312367426486540
[cit.8989567601554093118156178
2019–03–91965676015569129185237305371430494
25].52205836015563125158177
DOI:54255836015580167193213
10.1161/CIRCULATIONAHA.106.653428.566758360155581131331872342883403774464715346076857418198688969821063113712161290131413671422148615071570162916871750180718661888
ISSN7583583601552380137216
0009-7322.78275836015559123187249290345405462523544
Dostupné83995836015579148194234302371439501
z:8929583601554770
https://www.90285836015565101144214260280327361453549645662
ahajournals.org/doi/10.1161/CIRCULATIONAHA.106.653428522059960155591271842102773453824515085335786016697067748208839519761022108011351155120912561311136314001470149515591631171017661844189419222008209021642244231723422396245125142536259926592717278028372897
23.52206154015767132157
Sabatine54046156015560119189247284310377440
MS,587261560155100159179
EM60806156015560159
Antman,62686156015575143180285342410430
Widimsky672761560155106133202227331378430491
P,7246615601556469
et73436156015562101
al.7472615601555884105
Otamixaban76066156015586127185290315370427497556624
for82586156015533100137
the84246156015539107169
treatment8622615601553976136192230335397465502
of91526156015569102
patients92826156015571129167192254322359407
with52206316015595122161230
non‑ST‑elevation54796316015581150220259315377409475502564622682720746815884
acute63926316015570128196236296
coronary67176316015569135173240310368405467
syndromes72136316015559117188259296363470533581
(SEPIA‑ACS178236316015544101159223247322359434505566621
TIMI8473631601557199200226
42):87286316015574132163183
a89406316015569
randomised,90386316015549108177248317424450496559631652
double‑blind,52206476015571138206276302364404476502527594664684
active‑controlled,59326476015555112154179237297337397462531568604670697722784854875
phase68356476015567136193239301
271646476015559
trial.725164760155367399155181202
The74816476015556126188
Lancet76976476015554114181238297335
[online].8061647601553093162187212279341370389
2009,84786476015559119184246262
374(9692),87686476015559115168201258321381439469487
787–79592836476015559118176232288346407
[cit.5220663601553487112151173
2019–03–25].54216636015573133189242309375434498554615649668
DOI:61186636015593180207227
10.1016/S0140–6736(09)61454–9.637466360155721271482012563123664104685305866407047738398979581019105111111173120412661318137214301493155916211638
ISSN8041663601553693150230
01406736.82996636015573128183247310368429490512
Dostupné88396636015594163209250317387456518
z:9385663601556285
htt-94986636015579116159192