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/26228043010757
Klin2698804301077091109157
Farmakol2875804301073774100175215253301320
Farm3215804301073774100175
2022;36(4):129-1353409804301074083124168183227271294336357372409447490519558595637
/40668043010771
KLINICKÁ41578043010771115135195215269315373
FARMAKOLOGIE4550804301073888135207262309369411471530551595
A51658043010749
FARMACIE5235804301073887134207261313333376
13556558026012657110166
HLAVNÍ4945207012671127198263336370
TÉMA5336207012658115205275
Význam305136501063675109150190245
terapeutického33103650106316399141176207248280298332368400442482
monitorování380736501065393135152184223259300337374415432
léčiv42543650106306297115153
při44223650106336986
optimalizaci452336501063974106124178218249267300341374392
dávkování493036501063877111147186223260301318
acykloviru526336501063972111147179218255273308349
LITERATURA34458001234978134189250318368438498567
1.3437400853648
Majewska4067410835588103138189216246279
A,7017410834155
Mlynarczyk-Bonikowska7717410835571103141174195226257291321342379417456471501538589616646680
B.14667410833649
4015307410833571
years1616741083316597118146
after1777741083325176110131
the1923741083226196
registration343841083215798114142166188223246262302342
of7018410834465
acyclovir:7828410833972107140157196230246269283
Do10828410835292
we11918410835894
need13018410834581118159
new14778410834481134
anti-herpetic16278410833978101117141181218240282319342359392
drugs?343941083385998137163187
Int546941083145274
J63594108324
Mol6759410835493109
Sci.79994108332658093
2022;23(7):3431.9079410833468101136148183218236271290302337373405436446
2.34310400853652
Nishii4091041083435884122137152
R,57610410833347
Mizuno6381041083526897135173211
T,86410410833039
Rehling91910410833367106121136174213
D,114710410834354
et121610410833254
al.12851041083304558
NUDT15135810410834287132164198228
polymorphism16011041083367591123181219241281319334360418
influences343114108314526985122157194225259285
the6431141083185690
metabolism74811410835489111143181219235249275332
and109411410832967105
therapeutic12141141083195691111144182217254276291322
effects15511141083315069103135158186
of175111410833554
acyclovir181911410832961941251391773431241083324768
and42712410833270109
ganciclovir.55112410833870108141156188203241273289310320
Nat8871241083447798
Commun.100112410834077135193230268281
2021;12(1):4181.129812410833468101132141171201218250264276310341372404413
3.34313400853753
Brandariz-Nuñez41313410834265100140181215238255286309358397437474506
D,93513410835365
Correas-Sanahuja101713410834786109132168202230253286321361395435475492525
M,155913410836277
Maya-Gallego16531341083629612916318723627128830434134314410833980
S,43914410834054
et51014410834165
al.5921441083395671
Neurotoxicity67914410835390130153192216255287304338355379415
associated11111441083396796136171188222245281323
with14511441083587599140
acyclovir160814410833973108142159199233250273
and189814410833979121
valacyclovir:3431541083326784118152188221238278312329352367
A726154108349
systematic7911541083336896121157217251275292325
review11331541083286398115151205
of135515410834465
cases.143715410833873101138166181
J1635154108331
Clin16831541083476380120
Pharm181915410834382116139200
Ther.34316410833373108130141
2021;46(4):918-926.50016410833570103136145180217236270288301337369401424460494528542
4.34317400853651
Abuhelwa40917410834079117155190206257290
Z,71417410833649
Beran7791741083336990123161
A,95517410833954
Venkataramany102417410833467105135168190223244277335367405436
BS,14751741083346679
et156917410833255
al.16391741083304658
https://pubmed.ncbi.nlm.nih.gov/35509998/1713174108336578112114816018720724528334318410833896131170183221253291307319358373430443481496534547585623654677712744776810845880915949974
–1332184108333
affiliation-1138018410832947658297112143165180217255278308
Concurrent170318410833774112144181202223257295316
nephrotoxicity34319410833772112150171208230267297313345360382416
and77419410833068107
neurotoxicity89619410833570108129166188225255271303318340374
induced12851941083135089127159193232
by153319410833667
oral16151941083355790105
valacyclovir173519410833063781101421762072232613432041083324768
in42720410831654
a496204108334
patient5452041083417495111145183205
with7652041083536891129
previously9092041083416296128144182220247262294
normal12182041083397799158190205
kidney14392041083314786124159191
function.16452041083205997129153168206245258
Cureus.1918204108342793432141083215592119132
2022;14(3):e23693.49121410833468101136148178209229262279291326360395429463496509
5.34322400853650
Kacirova4072241083326698112133170202234
I,65622410831325
Urinovska6962241083416277115153184211240273
R,98522410833246
Sagan104622410833062101133171
J.123222410832133
Therapeutic128122410832968103124156195230268290305337
monitoring163322410835492130145167204225240278317
of196522410833453
serum3432341083266182121178
concentrations53723410832966105137171209230252285306322360398424
of97723410833555
acyclovir10472341083306296127143181213228249
and131223410833068107
its14342341083133663
metabolite151323410835590113146185224240254277311
9-(carboxymethoxymethyl)1839234108332567610613916034324410833978109143203238261300339369404463499521560591607627
guanine98624410834482114153168207242
in124424410832058
routine131824410832664103125141180215
clinical15492441083365267106121154187203
practice.176724410834466100133157173205239252
Biomed3432541083355189147182221
Pharmacother.58025410833572105126184217249286308346381402412
2022;156:113852.100825410833468101136148178208242255285312342377411444456
6.34326400853652
Ärlemalm4092641083476884119177210225283
A,70726410834761
Helldén78326410835085101116155190228
A,102726410834660
Karlsson11032641083407395111137164202241
L,135926410833750
et142526410833961
al.15022641083375265
Rapid158326410834173113128167
determination1766264108343781011351562152303432741083387092107145183
of54227410833656
acyclovir,6132741083316397128144182214229251260
its8892741083143664
main96827410835789104142
metabolite112627410835691114147186225241255278312
9-carboxymethoxymethylguanine,1453274108334579112414518422325428734638140344248051054434328410835893116155186202242280313351367405441453
ganciclovir,81128410834477115148163196212250283299320330
and115728410833776115
penciclovir128828410834480119152167199215254286302324
in162728410832059
human170228410834381139172211
serum19282841083326734329410832159116
using4742941083356176113152
LC-MS/MS.6412941083296881137169194249282295
Biomed9512941083334886144178218
Chromatogr.11842941083377596133191223245281321342352
2022;36(4):e5315.15512941083326598133145180214233265283294329363396427456468
7.34330400853643
Sadjadi4003041083296199113144181196
SA,6103041083296881
Regmi70630410833165103160174
S,89430410832941
Chau94930410833673104140
T.110430410832937
Acyclovir115530410833868100130145181212227247
neurotoxicity141630410833468104124160181217246260291305326359
in178930410831148
a1851304108328
peritoneal189430410833569891043433141083215794128159173
dialysis531314108334487994124150164189
patient:7343141083356788102136173193206
Report95431410833265103141162185
of115431410833352
a1220314108328
case12623141083286085119
and139531410832966103
review1513314108317508196129179
of170631410833452
the17733141083185589
pharmacokinetics18763141083357310412434332410835789120157187202239274295310341368
of72632410833655
acyclovir.7963241083316295126140178209224245254
Am106532410834097
J1177324108323
Case12153241083397197132
Rep.136132410833569108119
2018;19:1459-1462.14953241083346798128140169199211240271303334357387418453486497
8.34333400853652
Maximova41033410835790121137195233265298
N,72333410834760
Nisticò7993341083476288111127158195
D,101033410834858
Luci108433410833471103118
G,121733410834660
et129233410833759
al.13663341083355063
Population144433410833875114152168200222237275313
pharmacokinetics1773334108341791121331912243433441083316797114151185207222254281
of63934410833453
intravenous707344108312507192124155189227265302328
acyclovir10503441083296194125140177209224245
in131034410831249
oncologic137434410833573104141156194233248279
pediatric166834410833671110125156178199214245
patients.1928344108336693433541083223772110131159173
Front5313541083325289128149
Pharmacol.69535410833673105126185217249286302315
2022;13:865871.102635410833468101135148178208219254289323357390423432
9.21387400853649
Gunness22037410834886124162197224251
P,24697410834044
Aleksa2528741083466196126155188
K,27327410833954
Bend28017410834075113152
J,29687410832941
et30247410833861
al.3100741083365164
Acyclovir-induced31807410834576110141157195227242264283299337376414446480519
nephrotoxicity:371574108341762138841083397798136157194225240272287310343357
the2510841083246398
role2623841083236076111
of27498410834059
the2824841083246297
acyclovir29368410833567100132147185217233254
aldehyde3206841083344988123161192230265
metabolite.34868410836095118150190229244259282316328
Transl2138941083335083121147162
Res.2316941083357097110
2011;158(5):290-301.24429410833468100127136166196230249283301313348382418442474509540550
10.21381040085377389
Al-Alawi22441041083526892135152186239256
AM,2517104108351109124
Al-Maqbali26581041083516892150185226267301318334
JS,30091041083346882
Al-Adawi31081041083516892135175210263279
M,340410410836680
et350110410834468
al.35861041083425973
Incidence,36751041083256599115213811410833975115148183196
patterns,235011410834580102128163185225253267
risk26331141083264370101
factors27501141083255993118156179207
and297411410833877118
clinical31081141083375469109125158192208
outcomes333211410834484107139178238274302
of365011410834464
intravenous37311141083205921381241083224478110145184223262289
acyclovir244312410833770104137152191224240262
induced27211241083205898137170204244
nephrotoxicity.298112410834479119159180218241279310326358374397431442
Saudi343912410833872110150165
Pharm362012410834179112134194
J.213813410832437
2022;30(6):874-877.219013410833468101136148183218237270289300335368399422458491525531
11.21381440085366678
Helldén22321441083437894109148183221
A,246814410834055
Odar-Cederlöf253814410834685118139159201235275310331347385404
I,295814410831326
Larsson29991441083316485113139177216
K,323014410833449
et329414410833355
al.33651441083304659
Death343914410834480112133172
delusion.3626144108337728812515116621381541083377689
BMJ.224215410833691116129
2007;335(7633):1305.238615410833468105137147182215248266300332366399416428458488522556568
12.21381640085366984
Helldén223816410835085101117156191230
A,248316410834761
Odar-Cederlöf256016410835292125146166209243283319340356395414
I,299016410832033
Diener303816410835167102141176197
P,325116410834145
et331216410833962
al.33891641083375366
High347116410834965104142
serum36291641083316788127185
concentrations213817410833168107139172211232254286308324362400426
of258017410833554
the26501741083205893
acyclovir27581741083306396128143181213229250
main302317410835688103141
metabolite318017410835590112145185223239254277310
9-carboxymethoxymethylguanine35061741083325689122143183222252286213818410835792115153191221255314349371409440456495533565603618656691
in284418410831856
renal29151841083245897129144
failure3075184108321557085123144178
patients32681841083427597112147185206234
with35171841083547092131
acyclovir-related36631841083356710113221381941083155385101122142164198213245267301340
neuropsychiatric249419410833974111133170209236269300338353385407428444476
side29851941083284382116
effects:31171941083355574108141165193205
an333719410833472
observational342419410833978105140161196229250266304342374390
study.21382041083264987126158168
Nephrol232220410834479119157178215231
Dial25692041083456092108
Transplant26922041083335083121147186202234272294
2003;18:1135-1141.300120410833468105138149179210223252280310343365396423455485494
13.21382140085366782
Helldén22352141083417691106144179216
A,246621410833852
Lycke25332141083285687117151
J,269921410832133
Vander274721410833363101139174194
T,295621410833039
et301021410833153
al.30782141083294456
The314921410833069103
aciclovir32672141083296175107122159191206227
metabolite350921410835489111143182220235250272305
CMMG213822410833994148192
is234522410831237
detectable23972241083356991124156180212251266300
in271222410831249
the27762241083195791
CSF288222410833770102
of299822410833554
subjects30662241083246099114148180204231
with33122241083476284122
neuropsychiatric3449224108334691061261632022282602913283432138234108332547591123
symptoms227623410832962120160182219277303
during259523410834178100115153192
aciclovir28022341083356883115130168200216237
and305423410833573112
valaciclovir31822341083356783115147162194210248280295317
treatment.35142341083254680112134192227265287300
J2138244108324
Antimicrob217724410834180101116174189221242280319
Chemother.251224410834077112170209231269304325335
2006;57(5):945-949.286324410833468104140152187220237270289301336372404426461497530541
14.21382540085366883
Cotard22372541083377495128149186
J.243825410832234
Du248725410834381
délire25832541083356985100120154
des27522541083357096
négations.286325410833570109141162177215253279292
Arch31702541083385990127
Neurol331225410834277114135172188
1882;4:152170,3515254108331629713014217618821724728021382641083346497109
282-296.226226410833468102122153187222236
15.21382740085366984
Robertson223727410834180120156177202230269308
KM,256027410834198112
Harvey268727410835082104139174205
CL,29082741083457791
Cunningham301527410834582120159174212252290323381
JM.34122741083298599
Acyclovir-352627410834779112144160198231247268288
-induced21382841083213776116154186221261
neurotoxicity241428410834479118139177199237268283316331354389
with28182841083567295134
a2968284108337
positive302128410834483111126149164197232
cerebrospinal32692841083377193127167189227254294309348381397
fluid3681284108323407893133
varicella21382941083326586101133167183198230
zoster23832941083266490114147169
PCR256729410833374109
result26922941083185279116132154
creating28612941083305185117139154192231
a3107294108330
management315229410835688126158197232290325363385
dilemma:35522941083365167101159217250262
a2138304108332
case21853041083316491126
report.23263041083215594133154179192
J2534304108324
Med257330410835590129
Case27183041083407299134
Rep.286730410833671110122
2020;14(1):156.300530410833468101135148178209228260274286316346380394
16.21383140085377187
Abdalla224231410834787128161177192225
S,248331410833952
Briand25513141083416379112151191
C,275831410834660
Oualha283331410835493126142181214
M,306331410836175
et315331410834063
al.32323141083385467
Population331531410834179119159175208230246285324
pharmacokinetics365531410834584117139213832410835790122159189206244279301316348376
of252932410833959
intravenous2603324108317547697130162196234273311337
and295532410833472111
oral30813241083396194109
acyclovir32063241083336699131146184216232253
and347432410833472111
oral36003241083396194109
valacyclovir37253241083336621383341083154780113145161199231247268
in242233410832058
pediatric249533410834480120135167189211226259
population276933410834483123161177209231247285323
to310833410832764
optimize318733410834383105120178194223257
dosing346033410834382108123162201
regimens.367633410832660100116213834410835791128154167
Antimicrob23203441083387697112168183214235272311
Agents264634410833775109147168195
Chemother.285634410833774108165203224262296317327
2020;64(12):e01426-20.31983441083316496130142178213232263293310322355390422452484517540570604616
17.21383540085377080
Abdul-Aziz223535410834788129169185209252284301331
MH,2583354108361108122
Alffenaar272235410836986106126162201235269291
JWC,303035410833191132147
Bassetti319335410834277105133169193218235
M,344435410836276
et353735410834164
al.36183541083385569
Antimicrobial37033541083488839347410832240102120156180221264283318336
therapeutic42897410834385124148184227266308333351387
drug46947410836185127169
monitoring488274108380122164182208248273291333376
in52767410833678
critically53727410835478971221401762123934841083153367
ill4019841083294764
adult41018410834689129147172
patients:42908410835490114132169210234265280
a458784108347
Position46528410835090119136161179220261
Paper.49318410835085127165189201
Intensive5150841083297094131172201218254291
Care54588410835691115152
Med.39349410835490130144
2020;46(6):1127-1153.40949410833570104138152187224244278297309340368399432452483511542576589
18.39341040085366985
Cies40341041083385387114
JJ,41631041083224658
Moore4236104108365103142163197
WS,444910410835588100
Miller4565104108352678297132153
K,473310410833347
et479510410833254
al.48641041083304558
Therapeutic493710410833069104125158197233270293308340
drug52921041083365795134
monitoring5441104108355931311463934114108322598096134173
of412211410833655
continuous-infusion419311410833066105126142180217255293320341357395413452478493531570
acylovir47781141083316396112150182198219
for50131141083175476
disseminated51041141083375278105140198213251283305339378
herpes5497114108337729339341241083387399
simplex40481241083243895133149183214
virus42771241083294465102128
infection44201241083124967101133157172209247
in468212410831249
a4746124108329
neonate479012410833469107144176197231
receiving50351241083185284117132164179216255
concurrent530412410832965103134172192214247284305
extracorporeal39341341083336487108140171206227266303324357388402
life4351134108312264578
support44431341083235997136173194218
and467513410832966103
continuous479313410832864101121136173209246283308
renal51161341083175087118133
replacement52641341083175088103134165198254288325346
therapy.39341441083226095116149188219229
Pharmacotherapy.417914410833572105126184217249286308346381402435474505515
2015;35(2):229-233.471014410833468100130141176209226260278290325360394418448483516529
19.39341540085366982
Euler40311541083367287122144
M,419015410835770
Axelsson427615410834376110126152178217255
G,454615410834760
Helldén46221541083468197112151186224
A.486115410834459
Differential49351541083486383102137158192230251267299314
diagnosis52641541083415688127165204230245271
of555115410834059
central393416410833164102123144176191
nervous41401641083356990124161199225
system43801641083235582104138195
involvement45901641083124980117133165198255290327349
in495416410831249
a5018164108329
patient50621641083366889104139176197
treated52741641083194074105126160199
with54881641083476284122
acyclovir.39341741083326497129144182214230251262
Ther421117410833272107128
Drug435417410834667106145
Monit.451417410835493131146169182
2013;35(4):417-419.471117410833569100130142177210227260278290324354384402439469499510
20.39341840085367287
Lycke40361841083295889119154
J,420518410832234
Andersen425418410833977116151172200235273
O,454218410834556
Svennerholm46131841083316195134172207228266305320378
B,500618410833446
et506818410833154
al.51371841083304558
Acyclovir521018410833970104135151189221237258
concentrations548318410832966104393419410833165103125146179201216254292319
in426819410831452
serum43351941083266182120178
and452819410833270109
cerebrospinal46521941083316486120159180218244283299337369384
fluid5052194108316337186125
at519219410833153
steady52601941083264982114153185
state.54611941083254881103137149
J3934204108324
Antimicrob397320410834180101116174189221242280319
Chemother.430820410834077112170209231269304325335
1989;24(6):947-954.46592041083346499133146181213232266284296331367399417452486521534
21.39342140085366981
Yang403121410833362100139
HH,41852141083428699
Hsiao42992141083426882114152
YP,44672141083326973
Shih45552141083438196133
HC,47042141083418295
et481421410833154
al.48832141083294457
Acyclovir-induced495521410833970103135150188220235256276292330368406438471511
neuropsychosis54812141083357010739342241083215897124157188226265291306332
successfully42812241083306799130164191217237276291306338
recovered46352241083245890127159194215249288
after49392241083355479113134
immediate508822410831876134169208224256277311
hemodialysis54142241083417613417339342341083385385101132160174200
in415023410832057
an422323410833775
end-stage431323410833977116139165189221261295
renal46242341083256098130145
disease47852341083435884119151178213
patient.50132341083447799114149187208222
Int52502341083205879
J5345234108329
Dermatol.5389234108351861071661983934244108322597487
2007;46(8):883-884.403724410833468104137146181217236270288300335370404426462497534546
22.39342540085357186
Schulz40362541083306199135150179
M,423025410835164
Schmoldt43092541083296198155192208246268
A,459225410833852
Andresen-Streichert465825410833876114135168194229266288319339360393408439477511532556
H,522925410834153
et529725410833153
al.53642541083294457
Revisited:5436254108332669811313915339342641083215492104
Therapeutic405226410833068102122154192226263285299330
and439726410832865103
toxic4514264108319558499130
blood46582641083355188125163
concentrations483626410832864101132165202222243275296310347384410
of526026410833453
more532726410835491112145
than54862641083195687124
110039342741083346293129
drugs40792741083385997136162
and425727410833270109
other43812741083375997132153
xenobiotics.455027410833064102140180195233255270302330344
Crit4909274108340617799
Care.50232741083407394128140
2020;24(1):195.517927410833468101135148183215234266280292322352386398
23.39342840085377692
Feldman40432841083448097138198232272
S,433228410834458
Rodman440728410834788129190224264
J,468828410833549
Gregory475328410835679115157197220256
B.502628410834761
Excessive510428410834479112147176204220255291
serum54122841083377497137198
concentrations393429410833271112146182222245268303327343384424452
of440329410835172
acyclovir449129410834579115148165205239257279
and478729410834585127
neurotoxicity.493029410835188128151190214253285302336353377413424
J5371294108337
Infect54252941083276788124159185
Dis.39343041083456187101
1988;157(2):385-388.40503041083346499135147177207240257291308320356390424446478513548562
24.39343140085367187
Urinovska40373141083436581120159191219250284
R,433731410833449
Kacirova440231410833468101117139177209243
I,466131410831427
Sagan470431410833266105138177
J.489731410832336
Determination494931410834581104138160219235274307329345384423
of538831410833656
acyclovir5460314108331649813139343241083155690107130
and408132410834080122
its42203241083224676
metabolite4313324108366103127162204245263279303339
9-carboxymethoxymethylguanide46693241083426810413916220424527831437541343747751855058664868571075078380184288291639343341083385595132
in408333410832161
human416033410834584144178218
serum43953341083326992132192
by460433410834578
ultra-high-performance46993341083446185108142166207224264304328370407430453492515576610650684719
liquid54353341083213878118134175
chromatography-tandem39343441083327498138201236261302345369405448490524549574610652694732794
mass4747344108379114144174
spektrometry.493934410834789128162189214254317355380405442455
J5412344108345
Sep547534410835392135
Sci.3934354108332658195
2021;44(16):3080-3088.404535410833570103135144180217238270302321333369404440476501534569605641656