1061
ONKOLOGIE3418043010760120167227269329388409453
/8148043010757
Onkologie.8918043010786135172220239288338356400415
2023;17(2):90-941326804301074487128172186223260280323345360404449479523569
/19148043010757
www.onkologiecs.cz48658043010765133201214262311348396415464514532576617652669709748
941828026012657115
HLAVNÍ341207012670127198263336370
TÉMA732207012658115205275
Role34136501063374106138
radioterapie49436501063476115133173204236272314348365397
v906365010637
léčbě9583650106306297133165
nádorů113836501064080119160196237
pankreatu139036501063370111147183215257285326
LITERATURA34161901234978134189250318368438498567
1.3407800853648
Gastrointestinal4037810834578105128149186202240261295322345360398431446
Tumor8647810833468125164185
Study1065781083335593132163
Group:12447810834566104142181193
Further1453781083337091115154189210
evidence1678781083356883122157195227261
of19547810833958
effective340881083345473107140164179212246
adjuvant601881083377691129162194232254
combined8708810833774132171187224259299
radiation1184881083265998113145167182220259
and14588810833775114
chemotherapy15878810833674109167206228266301322355394425
following34098108319577388127179195233273
curative629981083367596130152168201235
resection880981083266188124157181197236275
of11709810834363
pancreatic12499810834477116149170205237259275308
cancer.15729810833770109142176198208
Cancer.17969810834579117150184206217
1987;59:2006-2010.3401081083346499132142177209223258292328364387418452484515528
2.34011800853652
Klinkenbijl4071181083415873111141176214254270285300
J,72311810832942
Jeekel78011810833065101131166182
J,97711810833042
Sahmoud103411810833872110168207245285
T,133411810833847
et139711810833962
al.14741181083375366
Adjuvant155611810834685100138171204243265
radiotherapy183611810832659991141523401281083226298120154194226
and58312810833777117
5-fluorouracil716128108340638299138177200238278300334367383399
after11311281083385783118140
curative12871281083377698132155171205240
resection15431281083276290126159184200240279
of183812810834464
cancer19181281083377134013810833870104126
of48113810834362
the55913810832765100
pancreas67513810834477116148169204236263
and95313810833776115
periampullary108413810834479101117149207247285301316348370404
region.150413810832660100115153192206
Ann172513810834685123
Surg.18641381083377597135148
1999;230:776-782.34014810833464100135148183217252265298333365388420453487499
3.34015800853651
Neoptolemos40615810834379117157179216232267324363390
JP,8111581083225863
Stocken8891581083315289122152186224
DD,112915810834389100
Friess12451581083305066100127154
H,141415810834356
et148515810833255
al.15551581083304659
Role16291581083347288123
of176715810833655
Radiation1837158108334671061211533401681083223775113
Therapy46816810833069104125158197228
in71116810831250
Pancreas77616810833365103134156189221248
Cancer103916810833770108140173194
randomized12491681083185188127165223238267301340
trial1605168108319405687103
of172316810833554
chemoradiotherapy1792168108329671011591973401781083215493108146167205240262294334365
and72017810832967106
chemotherapy84217810832966101159197219257292313346385417
after12741781083294873107128
resection14171781083195379114147171186224262
of169517810833554
pancreatic1764178108336691071391611952263401881083223769
cancer.42418810833164102134168189200
N639188108345
Engl69918810833370109125
J839188108324
Med.87918810835489129142
2004;350:1200-1210.103618810833468104141153188221255268298327362398422452482514545558
4.34019800853651
Regine40619810833367106121158193
W,61419810835464
Winter69319810835470107129162183
KA,8911981083327689
Abrams9951981083387799131188214
R,122419810833346
et128519810833253
al.13531981083294557
A1425198108338
phase147819810833674106132167
III16601981083122742
Intergroup17171981083124970104124162183220257296
trial340208108322435991106
(RTOG4612081083195488135180
97-04)6562081083346785122159176
of84720810833757
adjuvant9192081083317086123156189227248
pre11832081083385994
and129220810833169108
post141620810833877103127
chemoradiation155820810833169104162200222254294309341362378416454
(CRT)3402181083195893127149
5-FU5042181083355791135
vs.6542181083325972
gemcitabine74221810833873131163178201233273288326361
(G)11182181083196281
for12142181083195678
resected13072181083215582117150174208247
pancreatic156921810833972110143164198230252267299
adenocarcinoma.18832181083327110634022810833876108141163194209247285343375389
Int7442281083135173
J832228108323
Radiat87022810833467106121153175
Oncol106022810834684117153169
Biol12452281083344987103
Phys.20006;66:S23-S24.136322810833471102129142178213249285321333369404417450484518540572605637650
5.34023800853752
Griffin4092381083507389109127145184
J,61023810833043
Smalley66923810833998132148164200233
SR,9182381083397590
Jewell102423810833066119155171187
W,122723810836575
et131823810834164
al.13982381083385468
Patterns14822381083427598123158180220248
of174623810834464
failure1826238108324597591130152187
after3402481083325278113135
curative4912481083377698132155171204240
resection7472481083266189125159184200239278
of104124810834464
pancreatic112124810834579118151173208241264280313
carcinoma.14502481083377193125141180219279312326
Cancer.179224810834680120153188210220
1990;66:56-61.34025810833464100135148184220232267302325362393402
6.34026800853652
Safran4072681083326584106139177
H,60026810834356
Winter67126810835773111133167188
K,87426810833449
Abrams93826810834180102135193219
RA,11722681083357892
et128026810833355
al.13512681083314659
Results14262681083346996133149171199
of164026810833756
the17122681083215994
randomized1821268108320539113016934027810835773102136176
phase53127810834483115142177
II72427810831935
portion77427810834483105130145183222
of101127810834362
NRG108827810835086131
Oncology/RTOG123427810835391124161177215255287310347381428473
0848172327810833975111147
evaluating1886278108339711043402881083155284106121159198
the5532881083195892
addition66128810832968107122144160198236
of91228810833554
erlotinib9812881083325369107129144182197236
to123228810831956
adjuvant13032881083306984121154187225246
gemcitabine156428810833671128161176198231270285323358
for19372881083165475
patients3402981083397293109143181203231
with5862981083536991129
resected7312981083235784119152176209249
pancreatic99529810834274113145166200232254269301
head131129810834075107146
adenocarcinoma.147329810833473108146184217250271302317355393452484497
J1986298108326
Clin3403081083405570108
Oncol.46330810834786118155171184
2017;35:4007.66230810833468100130139174207218253289325357364
7.34031800853644
Ren40031810833368105
F,52131810832935
Xu57131810833671
YC,6583181083327083
Wang75631810835586124162
HX,9343181083417992
et104131810833254
al.11103181083294457
Adjuvant11823181083397792129161194232253
chemotherapy,145031810832966101159197218256291312345383415424
with18893181083486386124
or34032810833758
without4133281083476284122160197219
postoperative64732810833674100123159198233253286307322354388
radiotherapy,10493281083185189104141163200234255287326357366
for14303281083165374
resectable15193281083175177112144167199238253288
advanced1822328108328679913116834033810833165104
pancreatic45933810833669107139160194225247262294
adenocarcinoma:76833810832968103140178211244264295310348386444476488
continue127133810832966104125140178215250
or153633810833556
stop?16073381083244784123148
Pancreatology.1770338108332641021341551892203403481083225974113152184194
2012;12(2):162-169.55034810833468100130142172202219253271283313344377398428460494505
8.34035800853651
Liao4073581083294476114
WC,53635810835594107
Chien6583581083377590124162
KL,8353581083326579
Lin9293581083284481
YL,10253581083336579
et111935810833153
al.11873581083294557
Adjuvant12603581083387691128161193231252
treatments15273581083204174106128185220258279307
for18493581083155374
resected1938358108318523403681083266193117150189
pancreatic54436810833669106138159193224246261292
adenocarcinoma:85236810832967102140177210242263294309346384442474486
a1353368108329
systematic13973681083235682105138196228249264296
review1708368108318528499133184
and190736810832967106
network3403781083387395148186207238
meta-analysis.59337810835793115148170202240273288320347362388401
Lancet101037810833165103135168191
Oncol121637810834786118155171
2013;14(11):1095-1103.140237810833468100130141171203222254281296308337369404438460491519550583596
9.34038800853649
Luo40438810833572110
Y.53038810833947
The59338810833675110
role7183881083246278112
of84638810834160
radiotherapy9213881083245796112150171210245266299338369
for13063881083225981
pancreatic140238810834275113145167201233254270302
malignancies:1719388108361931091241622002332713403981083314681108120
a476398108334
population‑based52539810834180120158173206227243281319342382415441476516
analysis105639810833472105120152179194220
of129139810834059
the13653981083256398
SEER147839810833567100136
database.16293981083407395127167200226261273
Clinical191839810834257723404081083385385117133
and48840810833270109
Translational6124081083335083121147163195217232270308341356
Oncology.98340810834786118155171209249281291
2022;24:76-83.128940810833468101136148183215227261292316352386398
10.3404180085366984
Neoptolemos43941810834277116155177213229264321359386
JP,8404181083225762
Palmer9174181083336480137172193
DH,112541810834387100
Ghaneh124041810834180112149184222
P,147741810833337
et153041810833153
al.15984181083304558
Comparison167141810833774132171203224240266304342
of34042810833757
adjuvant4124281083317086123156189227248
gemcitabine67642810833872130163178200233272288326361
and105242810833169108
capecitabine117642810833164103138171186209241281296334369
with15604281083516689127
gemcitabine17024281083387313116317820123327328834043810833873
monotherapy42843810836099137175197235270292325364395
in83843810831856
patients9094381083427597112147185206234
with11584381083546992130
resected13034381083245885120153177210250
pancreatic156843810834275113145166200232254269301
cancer1885438108334671053404481083316586
(ESPAC-4):4414481083185185120157196210246264276
a732448108331
multicentre,77844810835794110132147179213251273294328340
open-label,113344810833776112150172189221260296311324
randomised,14724481083205391130168226241268303342355
phase184244810833876109135170
3340458108334
trial.389458108322445991107119
Lancet.52445810833165103135168191204
2017;389(10073):1011-1024.74345810833569100130140175209243262294326362394429446458487519551578597628659692724737
11.3404680085366678
Ghaneh43346810834381114152187225
P,67346810833438
Kleeff7274681083335085120140159
J,90146810832335
Halloran9514681083437590106144165198236
ChM,120346810833876131145
et136346810833255
al.14334681083304659
The150746810833170105
impact162846810831371110143175199
of184246810833656
positive191346810833776340478108326406277109143
resection4984781083185177112144167182220257
margins77047810835586107144159196222
on100747810833472
survival10944781083236081115130162195209
and131847810832967105
recurrence14384781083185183121141163196233265298
following1751478108316536883120171186223261
resection3404881083215581116149173188226264
and62048810832967106
adjuvant7414881083306984121154187225246
chemotherapy100348810832866101159197219257292313346385416
for14354881083165375
pancreatic152548810833669107139160194226248263295
ductal183548810833673106130162178
adenocarcinoma.34049810833271106144182215248269300315353391449482495
Ann85049810834180118
Surg.9834981083327091129142
2019;269(3):520-529.114049810833569100131143178212246265299316328363396430454488521555566
12.2140780085366883
van22387810832962100
Dam23537810834375132
JL,2501781083215367
Janssen2583781083225391117144179216
QP,2815781083448084
Besselink2915781083326794120155171185223253
MG,31837810835296110
et33087810833153
al.3376781083294557
Neoadjuvant34497810834277115148187202239272304342363
therapy2140881083226095116149188219
or23758810833557
upfront2447881083367594116154192214
surgery2676881083246283121156177211
for2902881083175576
resectable2994881083195379114147171204243259294
and33038810833068107
borderline3426881083377697135170191207222260295
resectable373688108319532140981083266194118151190206241
pancreatic23969810834073111144165199231253268300
cancer:27119810833366104136170191205
A293198108343
meta-analysis29899810835994117150172204242275290322349364390
of33949810833958
randomised3468981083225593132170229244270305345
controlled214010810833168107128150187203218253292
trials.2448108108321435890106132145
European26081081083337091128168203235273
Journal289610810832563101122161193208
of312010810833756
Cancer.319210810834072110143176197208
2022;140-149.341510810833468101136148178210245269300331364375
13.21401180085366782
Versteijne22371181083336586113135169183198236270
E,252211810833043
Suker25801181083296696129150
M,274511810835164
Groothuis28241181083416299137159196233248274
K,311311810833246
et317411810833153
al.32421181083294456
Preoperative33131181083335386125164199219252273288320354
Chemoradiotherapy368211810833774109214012810835897120153193209248270309345367401441473
Versus26291281083417597125163190
Immediate283412810832180139175215231263286320
Surgery31701281083397799137173195230
for34161281083246284
Resectable351612810834177105141174199232272214013810831550
and220513810833775114
Borderline233513810834079100139174195211226264299
Resectable264913810834176103138171195228267283318
Pancreatic298213810834173111143164199230252268300
Cancer:329713810834578116148182204217
Results353013810834075102140155177205
of375113810834261
the21401481083226095
Dutch225014810834584106137175
Randomized244014810833668107146184242257286320360
Phase281514810833573105132167
III29971481083153045
PREOPANC305714810833671104152188225270311
Trial.3384148108332496597112125
JCO.352514810832465110122
2020.366214810833468101135148
14.21401580085366984
Suker223915810833774104138159
M,241415810835872
Nuyttens250115810834886118143167201239265
JJ,27821581083285264
Groot286115810834869106145167
Koerkamp304315810833977112133164197255294
B,335315810833952
et342015810833860
al.34951581083365164
FOLFIRINOX357515810833683116148163199215214016810834490126
and228116810832865103
radiotherapy23981681083185087102139160197230251283321351
for27631681083165273
locally28501681083124981112127141172
advanced30361681083296798130167198231269
pancreatic331916810833567104135156189219240255286
cancer:36191681083286097128160180194
A2140178108341
cohort219617810833268107145167191
study.24031781083264987126158168
J2586178108325
Surg26261781083327091129
Oncol.277017810834786118155171184
2018;118:1021-1026.296917810833468100131143174201232245274306339370389420451484518531
15.21401880085366883
Neoadjuvant223818810834378116149188204241274307345366
FOLFIRINOX261918810833078110143157193209254302339
versus29731881083296485112149176
neoadjuvant316418810833570109142181196233266299337358
chemoradiotherapy35381881083296710215919821925221401981083385391113151186207240280311
and246619810833270109
adjuvant25911981083327186124157189227249
chemotherapy285519810833270105163201223261296317350390421
for32911981083195778
(borderline)33851981083185897118157191213229243281316334
resectable37341981083215521402081083266193117150188204239
pancreatic239420810833669106138159193225246261293
carcinoma:27022081083296182113128165203261293305
the30232081083195791
PREOPANC-2312920810833368101148184221266306320350
study.34952081083234684122154164
Available36742081083386910111621402181083154786102137
from:22922181083194178136148
https://www.24562181083375983123149162189209260314367378
trialregister.nl/trial/7094.2849218108322435991106127161201216242265299320330369385410433454470502517543579612647683695
16.21402280085367086
Katz22412281083417597128
M,238422810836074
Shi24742281083377691
Q,258122810835266
Meyers266222810836096128162184211
A,288922810834661
et296522810834062
al.30432281083375366
Efficacy3124228108338567492125158190224
of336422810834262
Preoperative34422281083406195135175210232265287303336370
mFOLFIRINOX214023810835791138170203218254270315363400
vs255623810833663
mFOLFIRINOX263523810836296143175208223259275320368405
Plus30562381083405592119
Hypofractionated319023810834981121160180202235267291307345383416438472511
Radiotherapy37172381083407321402481083395493115154190211245285317
for24722481083246284
Borderline257224810834180102141177198215230268304
Resectable289224810834176104139173197231271287322
Adenocarcinoma323024810834786121160199232266287319334373412471504
of375024810834363
the21402581083226095
PancreasThe225025810833466104136158192223250279318353
A021501261825810834074107138168202234
Phase286725810833572104131166
23048258108333
Randomized309725810833467105144182240255284318358
Clinical34702581083395469107122154187202
Trial.3688258108331486496111124
JAMA214026810832464120162
Oncol.231726810834786118155171183
2022;8(9):1263-1270.251626810833468101136148183202235253265294324358392414444474507540553
17.21402780085366876
Ghaneh223227810834786118156191230
P,247727810833943
Palmer25352781083397186144179200
D,275027810834960
Cicconi28252781083445991122159197212
S,305327810833548
et311727810833759
al.31922781083355063
Immediate327027810831976134169209224256278311
surgery35972781083296788126161182216
compared214028810833168126164197218252291
with24462881083486486124
short-course25852881083246199120145164198234272293320355
neoadjuvant295528810833570108141180195232264297335356
gemcitabine332628810833670128160175197230268284321356
plus36972881083365289115
capecitabine,214029810833163101136168183205237275290327362373
FOLFIRINOX,252829810833076108140154189204249296332345
or288829810833455
chemoradiotherapy295829810832865100156194215247286300338359396431451484522553
in352529810831249
patients35892981083366889104138176196224
with21403081083506587124
borderline22793081083367495133167187203217255289
resectable25833081083185177112144167199238253287
pancreatic288530810833668106137158191222244258290
cancer31903081083286097129162183
(ESPAC5):33883081083154881115152190225243254
a3657308108329
four-arm,370130810831552902140318108321407394152165
multicentre,232031810835593108130145177211249270292326338
randomised,26733181083185189128166225240266301340353
phase304131810833675107134168
23225318108332
trial.3272318108319415688103116
Lancet340431810832962100132166188
Gastroenterol36073181083427410112414518221403281083347294127149186202
Hepatol.235732810834479118151173210226239
2022.261132810833468101136149
18.21403380085366985
Hammel224033810834274132190225241
P,249633810833337
Huguet254933810834179118156190213
F,277733810833036
van282833810833063101
Laethem29443381083296297119158193250
JL,32103381083225467
et329333810833153
al.33623381083294558
Effect34353381083304968102135159
of360933810833555
Chemoradiotherapy367933810833875110214034810835693114146184198235256293327347379417447
vs260234810832854
chemotherapy26703481083286599155192213250284305336374405
on308934810833471
survival31753481083235979112127159191205
in339534810831148
patients34583481083356787102136172193220
with36923481083476284120
locally21403581083155283115130145175
advanced23303581083296798130167198231270
pancreatic261435810833668105136156190220241256287
Cancer291635810833668105136169190
controlled312035810832864102122143179195209243281
after34163581083294771104124
43555358108331
months360035810835491129150187212
of214036810833757
gemcitabine221236810833974132164179201234273289327362
with25893681083526790128
or273236810833860
without28073681083526790128166204227
Erlotinib:30493681083345470108130146183199238250
the33143681083236196
LAP07342536810833376111146179
randomized36193681083225593132170214037810835772102136175
clinical23303781083324762100115147180195
trial.2540378108322445991107119
JAMA.267537810832464119161176
2016;315(17):1844-1853.286637810833569100132144179210240258289319338350380411447484507538569603636649
19.21403880085356780
Krishnan2235388108332546994131169200237
S,248738810833042
Chadha254438810833774105143181212
AS,27713881083387183
Suh286938810833066104
Y,298738810833340
et304238810833153
al.31103881083284356
Focal31813881083296597130144
radiation33403881083185089103134156170208245
therapy36003881083195690111143182212
dose214039810833875102136
escalation22913981083325890122137169190205243281
improves258739810831269108129166197231258
overall28603981083346699120153168183
survival30583981083236081115130162195210
in328339810831249
locally33473981083135083115130145176
advanced353839810832968100133170202235274
pancreatic214040810833972110142163197229251266298
Cancer245340810834375113146179201
patients26694081083417496111146184205233
receiving29174081083235790124139171187225264
induction31964081083175594132164188203241280
chemotherapy34914081083347210716520322526329821404181083215493124
and227941810833775114
consolidative240841810833673112138176192207246278300315348382
Chemoradiation.280641810834482117175213235268307322354376391429468481
Int33024181083205879
J3396418108329
Radiat344141810834073112127159181
Oncol363741810835290122159175
Biol21404281083355189105
Phys.226042810833572103130144
2016;94(4):755-765.241942810833468100131143179215234267285296330363395417448480514526
20.21404380085377591
Rudra224743810834282122145179
S,244243810834053
Jiang25124381083314780120160
N,268943810835265
Rosenberg277143810834282110147186227264287326
A,311443810834863
et319343810834165
al.32744381083395569
Using33594381083517894133174
adaptive354943810833979113154177194228263
magnetic214044810835892132171207230246279
resonance24344481083276290129168202241274308
image-guided275844810832180113153189213254293309349384425
radiation319944810832660100116149171187226266
therapy348144810832766102124158198231
for37274481083246385
treatment21404581083224580113136196232272294
of245045810834464
inoperable253045810832160100141178200234275291328
pancreatic287445810834579118152174209242265281314
cancer.320545810833771111144179201212
Cancer343345810834781120154189211
Med.366045810836198139153
2019;8(5):2123-2132.214046810833468100130143178197231249261296328358392414445477507539552
21.21404780085367082
Reyngold223747810833570101140179217233272
M,252547810835367
Parikh26074781083346687103133172
P,279547810833439
Crane28494781083396093131166
ChH.303047810833977122135
Ablative31814781083407995127149164197231
radiation34284781083195292107139160176214252
therapy3695478108321609521404881083215392124
for22794881083165375
locally23694881083125083116131146177
advanced256248810832968100133171203237276
pancreatic285348810833669107139160194226247263294
cancer:31634881083286199131165186199
techniques33784881083195285123161176214252286313
and370648810833067106
results.21404981083215582119134156184198
Radiat235349810833568107122154176
Oncol.254549810834685117154170183
2019;6:4(1):95.274349810833569100131143179192226245277292303339373385
22.3940780085367288
Petrelli4043781083356891112146162177192
F,42507810833238
Comito43037810834077135150172209
T,45287810833241
Ghidini4584781083438297136151189204
A,48037810834055
et48737810833356
al.4944781083314659
Stereotactic5019781083325386108142180202235267291307339
body53737810833877117148
radiation553778108320533940881083385384105120158196
therapy4151881083195691112144183214
for4380881083155274
locally4469881083124981114129144175
advanced46598810832967100132170201234273
pancreatic49478810833669106138159192224245260291
cancer:5253881083296199130164184198
a546688108329
systematic551088108323558239409810832255113146167183215
review4170981083255991107142193
and43789810833674113
pooled45069810834382121137172211
analysis47329810833675107122154181196222
of49699810834261
1950459810833969
trials.512998108326476395110136150
Int5294981083195779
J538898108329
Radiat54329810833972111126158180
Oncol394010810834786118155171
Biol41261081083355189104
Phys.424610810833572103130144
2017;97(2):313-322.440510810833468100129139175207224258276288323354384406438471505518
23.39401180085367287
de404311810834075
Geus413311810834580118144
SWL,429311810833392124138
Eskander44461181083346291125163202237258
MF,47191181083568995
Kasumova48301181083366996133191229261294
GG,513911810834590103
et525811810833557
al.53301181083334962
Stereotactic5407118108334558911014418339401281083225487111126158
body411312810834079119151
radiotherapy42791281083225594109147169207242263296335367
for46611281083195779
unresected47551281083387698132158193226250284324
pancreatic509412810834073111143164198230252267299
cancer:540812810833366104136170191205
a3940138108332
nationwide39871381083387092107145183234249288323
review.43261381083205487102137188199
Cancer.454013810834073111143177198208
2017;123(21):4158-4167.476413810833468100129139169199234252286317332344378408438472495532562593626632
24.39401480085367187
Iacobuzio-Donahue40431481083175083120161200230246285309356396435468507545581
CA,46401481083418599
et475514810833659
al.48301481083345063
DPC4490914810834884126159
gene508414810834075114150
status52501481083285285108146173
of543914810833959
the55141481083246398
primary39401581083396279139173196232
carcinoma41881581083387395128144184224284318
correlates452315810833877100123159176209233268296
with48361581083587599138
patterns499115810834680103129165187228256
of526315810834465
failure5345158108324597692132154190
in555215810832160
patients39401681083397295111146185207236
with41921681083557295134
pancreatic434216810834477116149171206238261277309
cancer.466716810833770109142176198209
J4892168108330
Clin49381681083456176115
Oncol.506916810835291124162179192
2009;27(11):527716810834074111147161196230247279308323335
1806-1813.394017810833466102138162194226258289302
25.39401880085367287
Oar404218810835083104
A,416118810834458
Lee423418810833569104
M,435418810835771
Le444018810833468
H,452418810834760
et459918810833759
al.46731881083355063
AGITG475218810834486102136179
MASTERPLAN:494618810835799133168202237274305348393406
a5367188108335
randomised54171881083245795134172394019810835874100136176
phase413219810834483116143179
II432719810832035
study43781981083325594134166
of456019810834363
modified4638198108364103143158177194229269
FOLFIRINOX492319810833886119153167204220266315352
alone52911981083375392131167
or547319810834365
in555419810832059
combination394020810833168126166181219251273288326365
with43202081083567194132
stereotactic44672081083325588110144182204237269293309341
body482320810834483122154
radiotherapy49922081083265998113151173211246268301340371
for53782081083246283
patients5476208108344779911439402181083347294121
with40772181083516689127
high-risk42192181083395492130153175190217247
and448121810833270109
locally46062181083155386119134149181
advanced480221810833372105138176208241281
pancreatic509821810834073111143164198230252267299
cancer.541221810833265103135169190200
BMC394022810833590131
Cancer.408622810834073111143177198209
2021;21:936.431022810833468101132141176207216251284318331
26.39402380085377490
Henke404723810835087126158193
L,425623810833852
Kashani432423810834277104143177216232
R,457223810834257
Robinson464523810834282123139178206245285
C,494623810834760
et502323810834063
al.51022381083385568
Phase518623810834281114142178
I5380238108321
trial54172381083285067100116
of554923810834464
stereotactic39402481083265084105140179201234267291307339
MR-guided429424810836097119160198213253288328
online46372481083438297113151186
adaptive483924810833776109149171187219254
radiation51092481083265998114146168184222261
therapy538524810832766101123156196227
(SMART)394025810831850104145181214236
for41912581083165375
the42812581083195791
treatment43872581083194174106127185220257279
of468125810833453
oligometastatic47502581083345065103141199233255288314337369391406438
or520325810833456
unresectable52742581083347293127153188220244276315394026810831550
primary40052681083416278135168189223
malignancies424326810836092107122161199231270302317351378
of463726810833958
the47102681083246297
abdomen.482326810833372112150208244282295
Radiother513326810833770109124162184222257279
Oncol.542726810834988120157173186
2018;126:519-526.394027810833468100131143173203237249285316346369403436470483
27.39402880085367179
Scorsetti40352881083306299121148183205229244
M,429528810835165
Comito437528810833774132147170207
T,459728810833039
Franceschini46512881083304982120152186212245282297335350
D,501628810834354
et508528810833254
al.51542881083294558
Is522728810831238
there52802881083205892114147
an544328810832967
oligometastatic55252881083355166394029810833774131165187218244266298319334365
state4319298108323457798131
in446429810831249
pancreatic452729810833668104136156189220241255286
cancer?48282981083286097128160181202
Practical50452981083325284115138153184215230
clinical5290298108328425693108139170185
considerations54902981083286310139403081083264180115136169190206244282308
raise4264308108318516692127
the44063081083205893
question.451430810833673108135158173211250263
Br479230810833355
J4862308108322
Radiol.489930810833366105120158174187
2020;51013081083326699133146
93:20190627.52623081083326476111145177207243278312345351
28.39403180085367288
Lee404331810833266102
G,416031810834457
Kim423331810833551109
DW,4357318108346103113
Oladeru44853181083486496135170191229
OT,47303181083477988
et483431810833456
al.49053181083324861
Liver49813181083324780114135
metastasis-directed51313181083589311514817519823125727229831936037539643046339403281083225594
ablative40503281083296883115137152184218
radiotherapy42843281083185189104142164202236257290329360
in465932810831350
pancreatic472432810833669107139160194225247262294
cancer50333281083296199131164185
offers52343281083345473107128155
prolonged54043281083365895110148187394033810833872110
time40653381083193490125
off42043381083355472
systemic42913381083235582104137194209240
therapy:45463381083185690111143181212225
Data47863381083427394126
from49273381083163774131
a5073338108328
multi-institutional511633810835491106127142164179216242265279301338360375412450482496
retrospective3940348108321557798136162201237270294309342376
study.43313481083264987126158168
Pancreas.451534810833567105137158192224251264
2021;50:736-743.479534810833468101132140175210223256290325348379410442455
29.39403580085367285
Bernstein40403581083336889128154177210225263
MB,431835810835288100
Krishnan4434358108332547096133171203241
S,469035810833043
Hodge474835810834280119158192
JW,49563581083217989
et506035810833254
al.51293581083294457
Immunotherapy520135810831370128165203241263301336357389394036810833970
and402536810833169108
stereotactic41493681083254882103137176198231263287302334
ablative44983681083317187119140156188223
radiotherapy47363681083205392107145167205240261294333365
(ISABR):51163681083183365106142178197209
a5340368108331
curative53863681083316890123144160192226
approach?394037810833271111132169202235272297
Nat42523781083457799
Rev436737810833570102
Clin44843781083405670108
Oncol.460837810834785118154170183
2016;13(8):516-524.480737810833468100131143173203221255273285320351382406440473505517
30.39403880085367388
Venkatesulu404338810834174113143177199233260297313350
BP,44093881083407781
Cheng-En450638810834583118156196218253291
Hsieh,48123881083507691126164177
Sanders500538810833771109148183205232
KL,52523881083417488
et535538810833962
al.54323881083375366
Recent551338810834176394039810833267106129
advances408539810833878112146185219254281
in438239810832160
radiation445839810832761101117150173189228268
therapy474239810832867103125160200233
of499139810834363
pancreatic507039810834580119152174210243265281314
cancer.540039810833872111145179202212
F1000Research39404081083336596133169207242269304337358390428
2018,438440810833974106137150
7(F100045504081083405689121153190226
Faculty479240810833767100138154176210
Rev):1931501840810834176109127139170200233265
Last52984081083377198121
updated:1454354081083428212215539404181083225595107137168
DEC412341810834679119
2018.425841810833468100131144
31.39404280085366981
Palta40364281083346581103136
M,418742810835366
Godfrey426942810834180120139161195227
D,451142810834354
Goodman458142810834180119158216249287
KA,48834281083337791
et499042810833254
al.50594281083304558
ASTRO513342810833973107144192
Guideline53404281083428095134169184199237272
Radiation394043810833568107122154176191229267
Therapy422343810833069104125158197229
for44674381083165475
Pancreatic455843810833264102134155189221243258290
Cancer:486443810833770108140174195209
Executive50884381083306397129167190205237272
Summary537543810833067125183215394044810832155
of401044810833857
an408344810833270
ASTRO416844810834276110147195
Clinical43784481083415671109124156189204
Practice45984481083355689121145161192226
Guideline.48394481083458398137172187202240275287
Practical51424481083365689121145161193226241
Radiation539844810833669108123155177192394045810833776
Oncology.403145810834786118155171209248280290
2019;9:322-332.433745810833468100130143178191226259294314347379412425
32.39404680085367085
Nelson40404681083427792117155193
B,424846810833345
Barrord43084681083336586107144165203
M,452646810835164
Wang460546810835586123161
K,478146810833347
et484346810833153
al.49114681083294457
Relationship49834681083326782114135150187225251289303342
of534046810833453
dose54084681083357399134
to555746810831955
vascular39404781083326591123161176209230
target41854781083235677116150173
volumes43734781083337187124182217244
and463247810833472111
local47584781083175588121136
failure4909478108320546984122143177
in510147810831754
pancreatic517147810834073111143165199231252268300
cancer54864781083336610439404881083316485
patients40404881083366890104139176197225
undergoing428048810833471110144165203240255293331
neoadjuvant462648810833569107140178193230263295332354
chemoradiation.499548810832865100157195216249287302333355370407445458
Front54684881083294985123144
Oncol.394049810834786118155171184
2022;12:906484.413949810833468101136148178208221256291327364400436449
KNIŽNÍ33357140286124271329430579637
NOVINKA102657140286148316448503653777930
Jan141862350106225286
Bauer151862350106336497127147
METASTAZUJÍCÍ14196417011074124174228278328382437498534561616641
KOLOREKTÁLNÍ20806417011053117164228282331387439493539602629
KARCINOM27286417011053116169224249313379456
Nová14186547011061113158204
paradigmata,1641654701105299131177230254306383429461508530
nové21896547011052103148194
výzvy2402654701104694137185233
Cílem141867370107517090134208
publikace1646673701074897146166184222264305347
je2013673701071862
podat2095673701074897147188215
srozumitelný2330673701073258105141189263281309352371419457
přehled2807673701074975118167185229280
o31066737010747
nových3173673701074795135179218266
poznatcích3459673701074998133182223250288307347395
v38746737010739
biologii,3933673701074868116135183234252271286
imunitě4239673701071791138186205233275
a45346737010740
diagnostice4593673701074867107157205253287316334375417
mCRC50306737010772124169221
ve5270673701074083
vztahu5373673701073978109150199246
k14186867010738
existujícím1476686701074887107139168216235254294312386
a18816867010746
nově19466867010753101141185
se2150686701073882
objevujícím22526867010752102121165206254273292332350424
možnostem26966867010778126162210259292321364437
léčby.3153686701072467109158197209
Stručně338268670107467299147188236280
jsou3681686701072457105153
vždy3854686701074584132172
popsány40466867010754103153186228276315
mechanismy43806867010778123164212253301319352425464
účinku4863686701075293111159197245
léčiv,5128686701072367108127168179
léčebné5327686701072367108150200249293
výsledky1418699701074184118137181231269311
jsou1749699701072456105153
obvykle19226997010752102142186224245289
uvedeny2231699701075293136186230278317
ve2568699701074488
formě2675699701072876103177221
tabulek2916699701073273123171190234272
nebo3208699701075397146196
grafů,3423699701075480122145194209
přičemž3652699701075481100140182256293
zahrnuty3964699701074183131158207254282325
jsou4309699701072356104152
pouze44816997010754103151188231
výsledky4732699701074588122141185235273316
z50676997010741
rozhodujících5128699701073178113162210260308327345385404444492
randomizovaných1418712701072768116166214288307343390431472520559598646
a/nebo2084712701074174120164214263
kontrolovaných2367712701073885134161187234254302343384432471510558
studií.2945712701073463111160179197213
Maxdorf14187314010770111151199247274301
2022,1739731401074487128172187
2961946731401074487132
str.,209773140107346390102118
barevné2234731401075092118161202251295
ilustrace,254973140107183785117146173215255298312
edice2881731401074494112153195
Jessenius,3096731401073175109142186235253300333349
ISBN:3465731401071960104161177
978-80-7345-730-3,3661731401074486128156202246276316359404445472512555598628669684
Cena:4364731401075294143183198
5954582731401074484127
Kč,472973140107367692
Formát:1418744401074289116190231258274
160×225mm,1712744401074483128193248292336421495510
brožovaná2242744401075076124159206246288336377
Maxdorf,14187630010770111151199247274301314
s.1752763001073350
r.1822763001071830
o.,187276300107395570
Na1962763001075798
Šejdru2080763001074286105154180229
247/6a,2328763001074484125149190232248
1422596763001074483124
002739763001074490
Praha2849763001074571112160201
4,3070763001074458
tel.:314876300107287090106121
2413289763001074484122
0113431763001074484118
681–9,3569763001074489129170214226
fax:3815763001072366105122
2413957763001074484122
7104099763001074484124
245,4243763001074484125139
www.maxdorf.cz,44017630010765133201214289329369417466493519533574612629
e-mail:1418776001074473147188207225240
info@maxdorf.cz167877600107196790138204278318358406455482508522563601