Jedinečná síla
dvojího účinku
Urapidil je jediné antihypertenzivum
V FHQWU¤OQ°P D SHULIHUQ°P ½ÐLQNHP
1
(EUDQWLO MH MHGLQÀ SHURU¤OQ° SĜ°SUDYHN
V ½ÐLQQRX O¤WNRX XUDSLGLO Y ÏHVN¬ UHSXEOLFH
2
=NU¤FHQ¤ LQIRUPDFH R O¬ÐLY¬P SĜ°SUDYNX
1¤]HY SĜ°SUDYNX
(EUDQWLO
UHWDUG (EUDQWLO
UHWDUG 7YUG¬ WRERON\ V SURGORXŁHQÀP
XYROċRY¤Q°P
6ORŁHQ°
-HGQD WREROND V SURGORXŁHQÀP XYROċRY¤Q°P REVDKXMH 8UDSLGLOXP
PJ QHER PJ 6H]QDP SRPRFQÀFK O¤WHN VH QDFK¤]° Y ½SOQ¬P 63&
,QGLNDFH
3Ĝ°SUDYHN
MH XUÐHQ N GORXKRGRE¬ O¬ÐEÞ K\SHUWHQ]H
'¤YNRY¤Q° D ]SljVRE SRG¤Q°
'RSRUXÐHQ¤ G¤YND
. SRVWXSQ¬PX VQ°ŁHQ° NUHYQ°KR WODNX VH O¬ÐED ]DKDMXMH G¤YNRX (EUDQWLOX UHWDUG GYDNU¤W GHQQÞ
RGSRY°GDM°F°
PJ XUDSLGLOX GHQQÞ 3RNXG VH Y\ŁDGXMH ÐL MH QH]E\WQ¬ U\FKOHMĤ° VQ°ŁHQ°
NUHYQ°KR WODNX O¬ÐED PljŁH EÀW ]DK¤MHQD G¤YNRX (EUDQWLOX UHWDUG GYDNU¤W GHQQÞ RGSRY°GDM°F°
PJ XUDSLGLOX GHQQÞ '¤YND PljŁH EÀW SRVWXSQÞ SĜL]SljVREHQD LQGLYLGX¤OQ° SRWĜHEÞ
5R]PH]° XGUŁRYDF° G¤YN\ MH DŁ PJ XUDSLGLOX GHQQÞ FHONRY¤ G¤YND VH UR]GÞO° GR GYRX
MHGQRWOLYÀFK G¤YHN
9ĤHREHFQ¬ SRN\Q\
7RERON\ V SURGORXŁHQÀP XYROċRY¤Q°P VH XŁ°YDM° SĜL
UDQQ°P D YHÐHUQ°P M°GOH D SRO\NDM° VH FHO¬ V WURFKRX WHNXWLQ\ (EUDQWLO WRERON\ V SURGORXŁHQÀP
XYROċRY¤Q°P MVRX YKRGQ¬ N GORXKRGRE¬PX XŁ°Y¤Q° /¬ÐED K\SHUWHQ]H SĜ°SUDYNHP (EUDQWLO
Y\ŁDGXMH SUDYLGHOQ¬ O¬NDĜVN¬ NRQWURO\
=YO¤ĤWQ° VNXSLQ\ SDFLHQWlj
9 SĜ°SDGÞ Y¤ŁQÀFK SRUXFK
MDWHUQ°FK IXQNF° PljŁH EÀW QH]E\WQ¬ VQ°ŁHQ° G¤YN\ (EUDQWLOX
8 VWDUÀFK OLG° D X SDFLHQWlj
VH VWĜHGQÞ WÞŁNÀP DŁ WÞŁNÀP SRĤNR]HQ°P UHQ¤OQ°FK IXQNF° PljŁH EÀW Y SĜ°SDGÞ GORXKRGRE¬
O¬ÐE\ (EUDQWLOHP QXWQ¬ SĜLPÞĜHQ¬ VQ°ŁHQ° G¤YN\
.RQWUDLQGLNDFH
(EUDQWLO QHVP° EÀW SRXŁ°Y¤Q
Y SĜ°SDGÞ SĜHFLWOLYÞORVWL DOHUJLH QD MDNRXNROL VORŁNX SĜ°SUDYNX
=YO¤ĤWQ° XSR]RUQÞQ°
=YO¤ĤWÞ
SHÐOLYÀ GRKOHG MH QXWQÀ X SDFLHQWlj VH VUGHÐQ°P VHOK¤Q°P ]SljVREHQÀP IXQNÐQ°P SRĤNR]HQ°P
PHFKDQLFN¬KR SljYRGX QDSĜ VWHQ¶]RX DRUW¤OQ° ÐL PLWU¤OQ° FKORSQÞ SXOPRQ¤OQ° HPEROL° QHER
SRUXFKRX VUGHÐQ° DNFH ] GljYRGX RQHPRFQÞQ° SHULNDUGX X GÞW° MHOLNRŁ QHMVRX N GLVSR]LFL
SĜ°VOXĤQ¬ VWXGLH X SDFLHQWlj V SRUXFKDPL MDWHUQ°FK IXQNF° X SDFLHQWlj VH VWĜHGQÞ WÞŁNRX DŁ
WÞŁNRX SRUXFKRX IXQNFH OHGYLQ X VWDUĤ°FK SDFLHQWlj X SDFLHQWlj NWHĜ° MVRX VRXÐDVQÞ O¬ÐHQL
FLPHWLGLQHP 3Ĝ°SUDYHN (EUDQWLO REVDKXMH VDFKDU¶]X 3DFLHQWL VH Y]¤FQRX GÞGLÐQRX LQWROHUDQF°
IUXNW¶]\ PDODEVRUSF° JOXN¶]\ D JDODNW¶]\ QHER VDFKDU¶]R L]RPDOW¤]RYRX GHILFLHQF° E\ QHPÞOL
WHQWR SĜ°SUDYHN XŁ°YDW
,QWHUDNFH
$QWLK\SHUWHQ]Q° ½ÐLQHN (EUDQWLOX PljŁH EÀW ]YÀĤHQ VRXÐDVQÀP
XŁ°Y¤Q°P EORN¤WRUlj DOID DGUHQHUJQ°FK UHFHSWRUlj YD]RGLODWDQFL° D MLQÀFK DQWLK\SHUWHQ]LY VWDY\
V QHGRVWDWHÐQÀP REMHPHP WHNXWLQ SUljMHP ]YUDFHQ° D DONRKROHP 6RXÐDVQ¬ XŁ°Y¤Q° FLPHWLGLQX
PljŁH ]YÀĤLW V¬URY¬ KODGLQ\ XUDSLGLOX R
-HOLNRŁ GRVXG QHMVRX GRVWXSQ¬ GRVWDWHÐQ¬ LQIRU
PDFH R NRPELQDFL O¬ÐE\ V $&( LQKLELWRU\ WDWR O¬ÐED VH Y VRXÐDVQ¬ GREÞ QHGRSRUXÐXMH
7ÞKRWHQVWY° D NRMHQ°
(EUDQWLO QHVP° EÀW SRXŁ°Y¤Q EÞKHP WÞKRWHQVWY° ÐL NRMHQ° MHOLNRŁ GRVXG
QHH[LVWXM° ½GDMH R MHKR SRXŁ°Y¤Q° X OLG° Y WÞFKWR REGRE°FK 6WXGLH QD ]Y°ĜDWHFK QHSĜLQHVO\ Ł¤GQ¬
GljND]\ SRĤNR]HQ° SORGX
1HŁ¤GRXF° ½ÐLQN\
9HOPL ÐDVW¬
t
ÐDVW¬
t
Ʃ
P¤OR
ÐDVW¬
t
Ʃ
Y]¤FQ¬
t
Ʃ
YHOPL Y]¤FQ¬ YÐHWQÞ RMHGLQÞOÀFK SĜ°SDGlj
6UGHÐQ° SRUXFK\ 0¤OR ÐDVW¬ SDOSLWDFH WDFK\NDUGLH EUDG\NDUGLH SRFLW WODNX ÐL EROHVW
QD KUXGL VW°ŁQRVWL SRGREQ¬ DQJLQÞ SHFWRULV *DVWURLQWHVWLQ¤OQ° SRUXFK\ ÏDVW¬ QHYROQRVW Ʃ
Y]QLN¤ ]YO¤ĤWÞ QD SRФWNX O¬ÐE\ D WR ] GljYRGX SRNOHVX NUHYQ°KR WODNX YÞWĤLQRX MH SĜHFKRGQ¤
0¤OR ÐDVW¬ ]YUDFHQ° D SUljMHP VXFKR Y ½VWHFK &HONRY¬ D MLQGH QH]DĜD]HQ¬ SRUXFK\ 0¤OR ÐDVW¬
½QDYD 9HOPL Y]¤FQ¬ RWRN ] GljYRGX UHWHQFH YRG\ $EQRUP¤OQ° NOLQLFN¬ D ODERUDWRUQ° Q¤OH]\
QH]DĜD]HQ¬ MLQGH 9HOPL Y]¤FQ¬ UHYHU]LELOQ° ]YÀĤHQ° VSHFLILFNÀFK MDWHUQ°FK HQ]\Plj VQ°ŁHQ° SRÐWX
WURPERF\Wlj E\OR SR]RURY¤QR Y ÐDVRY¬ VRXYLVORVWL V XŁLW°P SHURU¤OQ°KR XUDSLGLOX DÐNROLY SĜ°ÐLQQ¤
VRXYLVORVW V O¬ÐERX XUDSLGLOHP QHPRKOD EÀW XUÐHQD QDSĜ LPXQRKHPDWRORJLFNÀPL Y\ĤHWĜHQ°PL
3RUXFK\ QHUYRY¬KR V\VW¬PX ÏDVW¬ ]¤YUDWÞ EROHVW KODY\ Ʃ ]YO¤ĤWÞ QD SRФWNX O¬ÐE\ MVRX
]SljVREHQ\ SRNOHVHP NUHYQ°KR WODNX D MVRX YÞWĤLQRX SĜHFKRGQ¬ 3V\FKLDWULFN¬ SRUXFK\ 0¤OR
ÐDVW¬ SRUXFK\ VS¤QNX 9HOPL Y]¤FQ¬ QHNOLG 3RUXFK\ OHGYLQ D PRÐRYÀFK FHVW 9HOPL Y]¤FQ¬
]YÀĤHQ° QXFHQ° QD PRÐHQ° ÐL ]YÀĤHQ° PRÐRY¬ LQNRQWLQHQFH 3RUXFK\ UHSURGXNÐQ°KR V\VW¬PX
D SUVRX 9HOPL Y]¤FQ¬ SULDSLVPXV 5HVSLUDÐQ° KUXGQ° D PHGLDVWLQ¤OQ° SRUXFK\ 0¤OR ÐDVW¬
XFS¤Q° QRVX 3RUXFK\ NljŁH D SRGNRŁ° 0¤OR ÐDVW¬ DOHUJLFN¬ UHDNFH MDNR VYÞGÞQ° ]ÐHUYHQ¤Q°
SRNRŁN\ Y\U¤ŁN\ &¬YQ° SRUXFK\ 0¤OR ÐDVW¬ VQ°ŁHQ° NUHYQ°KR WODNX SĜL ]PÞQÞ SRORK\ QDSĜ
YVW¤Q° SR SR]LFL YOHŁH RUWRVWDWLFN¤ K\SRWHQ]H
'RED SRXŁLWHOQRVWL
URN\
8FKRY¤Y¤Q°
8FKRY¤YHMWH Y GREĜH X]DYĜHQ¬ ODKYLÐFH DE\ E\O SĜ°SUDYHN FKU¤QÞQ SĜHG YOKNRVW°
'UŁLWHO
UR]KRGQXW° R UHJLVWUDFL
7DNHGD *PE+
.RQVWDQ] 1ÞPHFNR
5HJLVWUDÐQ° аVOR
(EUDQWLO
UHWDUG
$ & (EUDQWLO
UHWDUG
% &
'DWXP UHYL]H WH[WX
3Ĝ°SUDYHN MH Y¤]¤Q QD O¬NDĜVNÀ SĜHGSLV D MH ФVWHÐQÞ KUD]HQ ] SURVWĜHGNlj
YHĜHMQ¬KR ]GUDYRWQ°KR SRMLĤWÞQ°
Literatura: 1.
Švejda J. Dnešní pohled na perorální urapidil v léčbě arterialní hypertenze.
Cor et Vasa
2009;51(2):138–141.
2.
Databáze léčivých přípravků
, ATC C02CA06.
Takeda Pharmaceuticals Czech Republic s.r.o.
Škrétova 490/12, 120 00 Praha 2,
(2
(%5
