35
APRIL 24
TH
– 26
TH
, 2014 | OLOMOUC | THE CZECH REPUBLIC
ABS TRAC T BOOK
KEYNOTE LECTURES OF INVITED SPEAKERS
Friday, April 25
th
, 2014 / 9.00–17.30
Lecture hall CODEX and SCRIPTUM
Retrospective survival studies in archive tissues
Stanta G.
Department of Medical, Surgical and Health Sciences,
University of Trieste, Italy
There is a lot of criticism in literature about clinical
retrospective studies, but these studies can be improved by
a better design and a better selection of cases. The second
problem of these studies, partially in common also with
the prospective ones, is the selection of tissues and their
microdissection related to the high level of heterogeneity
usually found in tumours. This is also related to lack of
standardization of the molecular methods used in archive
tissues, starting from extraction of nucleic acids. Only with
a correct microdissection and with stardardized methodologies
it is possible to obtain reproducible results that can be
informative for clinical development. These archive tissues
will be increasingly important in the future to better subgroup
therapy patients, to recognize new acquired resistance
biomarkers, to establish the real efficacy of the new therapies.
Today the major European organizations are starting to
improve the quality of these studies with specific working
groups and increasing the collaboration with the already
developed biobanking system in Europe (BBMRI).
Possibilities within a collaborative network
on gyneco-oncology – a model from Lund,
Southern Sweden
Måsbäck A.
Pathology department, Lund University Hospital and
Laboratory Medicin in Scania, Sweden
Background
Sweden is a nation of approximately 9 million inhabitants,
most hospitals are public, and there is an ongoing process of
centralization of cancer treatment with tumour centers. Today
there is about 6 major and some minor university hospitals trea-
ting the vastmajority of cancer patients. Involved in gynaecologic
tumours treatment are gynecologists, gynaecologic surgeons, and
gyneco-oncologists, radiologists, pathologists and radiotherapists.
Multidisciplinary regional work
In the Southern Sweden Health Care Region there are
several meeting forms enabling an exchange of knowledge
and experience. Each week there is an allocated reception,
including a surgeon and an oncologist, with possibility to exa-
mine patients before decision of surgical treatment. MDT (Multi
Disciplinary Tumour) conference is held each week, where
patients can be discussed before further treatment, including
surgeons, oncologists, radiologists and pathologists. Regional
meetings is held twice a year where all doctors working with
gynecologic tumour patients are invited. This personal contact
is important to facilitate continuous communication concer-
ning patients or logistic issues.
Reference pathologist
As reference pathologists in this organisation there are
several areas of responsibility/liability.
Local:
The main task is to see to that the surgical specimens are
diagnosed correctly, and promptly if possible, the aim is within
two weeks.
Since new techniques and research projects are continu-
ously introduced there are always logistic problems to solve.
Regional and national:
The main task is to keep up the communication between
and education of the fellow pathologists in Sweden and
to standardize and improve diagnostic activities based on
scientific results.
The novel estrogen receptor – GPER – in estrogen
sensitive malignancies
Kolkova Z.
1
, Ehinger A.
2, 5
, Mörgelin M.
3
,
Jirström K.
4
, Hansson S.
1
, Casslén B.
1
1
Department of Obstetrics & Gynecology
2
Department of Oncology
3
Department of Infection Medicine
4
Department of Pathology & Cytology, Lund University,
Skåne University Hospital Lund, Sweden
5
Department of Pathology & Cytology, Blekinge Hospital,
Karlskrona, Sweden
Estrogen effects are mediated either through genomic
action involving the classical estrogen receptors, estrogen
receptor alpha and beta, which function as transcription fac-
tors in the nucleus, or through rapid non-genomic action via
receptors associated with membranes in the cell. Recently,
a member of the G protein-coupled receptor family was ascri-
bed estrogen receptor properties, thus a candidate for me-
